LY-503,430

Base Information

Chemical Name:LY-503,430
CAS No.:625820-83-9
Molecular Formula:C20H25FN2O3S
Molecular Weight:392.4875032
Hs Code.:

Synonyms:LY-503,430

Suppliers and Price of LY-503,430

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

American Custom Chemicals Corporation
4'-((1S)-1-FLUORO-2-[(ISOPROPYLSULFONYL)AMINO]-1-METHYLETHYL)-N-METHYLBIPHENYL-4-CARBOXAMIDE 95.00%
5MG
$ 503.97

Total 0 raw suppliers

Chemical Property of LY-503,430

Chemical Property:

PSA：83.65000
LogP:5.08830

Purity/Quality:: 4'-((1S)-1-FLUORO-2-[(ISOPROPYLSULFONYL)AMINO]-1-METHYLETHYL)-N-METHYLBIPHENYL-4-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of LY-503,430

There total 10 articles about LY-503,430 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 10147-37-2
Isopropylsulfonyl chloride

: 1246973-56-7
(S)-4'-(1-amino-2-fluoropropan-2-yl)-N-methylbiphenyl-4-carboxamide

: 625820-83-9,305447-09-0
(S)-4'-[1-fluoro-1-methyl-2-(propane-2-sulfonylamino)-ethyl]-biphenyl-4-carboxylic acid methylamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/ol1019579

Reference yield:

: 13329-40-3
4-Iodoacetophenone

: 625820-83-9,305447-09-0
(S)-4'-[1-fluoro-1-methyl-2-(propane-2-sulfonylamino)-ethyl]-biphenyl-4-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 10 steps

1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 - 30 °C / Inert atmosphere; Large scale

2: triethylamine tris(hydrogen fluoride); N-Bromosuccinimide / n-heptane; dichloromethane / 0 - 25 °C / Large scale

3: tetrabutylammomium bromide / N,N-dimethyl-formamide / 7 h / 150 - 155 °C / Large scale

4: water; ethanol / 26 h / 20 - 25 °C / Large scale

5: water; propan-1-ol; tert-butyl methyl ether / 3.5 h / 65 - 70 °C / Large scale

6: sodium hydroxide / tert-butyl methyl ether / 0.58 h / 19 - 30 °C / Large scale

7: triethylamine / tetrahydrofuran; toluene / 2.35 h / -5 - 30 °C

8: potassium carbonate; palladium / methanol; water / 1 h / 63 - 68 °C / Inert atmosphere

9: ethyl acetate / 1.5 h / 22 °C / Large scale

10: tetrahydrofuran; ethyl acetate / 22 - 50 °C / Large scale

With N-Bromosuccinimide; potassium tert-butylate; tetrabutylammomium bromide; potassium carbonate; palladium; triethylamine tris(hydrogen fluoride); triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; propan-1-ol; ethanol; n-heptane; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 1: |Wittig Olefination / 3: |Gabriel Amine Synthesis / 8: |Suzuki Coupling;
DOI:10.1021/op0500741

Reference yield:

: 2-fluoro-2-(4-iodo-phenyl)-propylamine

: 625820-83-9,305447-09-0
(S)-4'-[1-fluoro-1-methyl-2-(propane-2-sulfonylamino)-ethyl]-biphenyl-4-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran; toluene / 2.35 h / -5 - 30 °C

2: potassium carbonate; palladium / methanol; water / 1 h / 63 - 68 °C / Inert atmosphere

3: ethyl acetate / 1.5 h / 22 °C / Large scale

4: tetrahydrofuran; ethyl acetate / 22 - 50 °C / Large scale

With potassium carbonate; palladium; triethylamine; In tetrahydrofuran; methanol; water; ethyl acetate; toluene; 2: |Suzuki Coupling;
DOI:10.1021/op0500741