4-Methylbenzo[c]cinnoline

Base Information

• Chemical Name: 4-Methylbenzo[c]cinnoline
• CAS No.: 19174-78-8
• Molecular Formula: C₁₃H₁₀N₂
• Molecular Weight: 194.236
• Mol file: 19174-78-8.mol

Synonyms:4-Methylbenzo[c]cinnoline

Chemical Property of 4-Methylbenzo[c]cinnoline

Chemical Property:

• Melting Point: 129 °C
• PSA: 25.78000
• LogP: 3.09140

Purity/Quality:

4-methyl-Benzo[c]cinnoline 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methylbenzo[c]cinnoline

There total 5 articles about 4-Methylbenzo[c]cinnoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-methylbenzo[c]cinnoline 5-oxide (945927-96-8) → 4-Methyl-benzocinnolin (19174-78-8)

Guidance literature:

With indium; ammonium chloride; In ethanol; at 80 ℃; for 1h;

DOI:10.1039/b618318b

Reference yield:

2-amino-benzeneboronic acid hydrochloride → 4-Methyl-benzocinnolin (19174-78-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / aq. Na₂CO₃; EtOH / Pd(PPh₃)4 / toluene / 12 h / Heating

2: 65 percent / NaOH / methanol / 0.02 h / 150 °C / Irradiation

3: 78 percent / indium; aq. NH₄Cl / ethanol / 1 h / 80 °C

With indium; sodium hydroxide; ethanol; sodium carbonate; ammonium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; toluene; 1: Suzuki coupling;

DOI:10.1039/b618318b

Reference yield:

1-bromo-3-methyl-2-nitro-benzene (52414-97-8) → 4-Methyl-benzocinnolin (19174-78-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / aq. Na₂CO₃; EtOH / Pd(PPh₃)4 / toluene / 12 h / Heating

2: 65 percent / NaOH / methanol / 0.02 h / 150 °C / Irradiation

3: 78 percent / indium; aq. NH₄Cl / ethanol / 1 h / 80 °C

With indium; sodium hydroxide; ethanol; sodium carbonate; ammonium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; toluene; 1: Suzuki coupling;

DOI:10.1039/b618318b

upstream raw materials:

4-methylbenzo[c]cinnoline 5-oxide

3'-methyl-2'-nitro-[1,1'-biphenyl]-2-amine

1-bromo-3-methyl-2-nitro-benzene

Refernces