Technology Process of 4-(3-Cyano-phenoxy)-2-pyridin-3-yl-pyrimidine-5-carboxylic acid
There total 4 articles about 4-(3-Cyano-phenoxy)-2-pyridin-3-yl-pyrimidine-5-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(3-Cyano-phenoxy)-2-pyridin-3-yl-pyrimidine-5-carboxylic acid ethyl ester;
With
water; sodium hydroxide;
In
ethanol;
at 20 ℃;
for 2h;
With
hydrogenchloride;
In
ethanol; water;
pH=2;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: caesium carbonate / acetonitrile / 2 h / 20 °C
2.1: sodium hydroxide; water / ethanol / 2 h / 20 °C
2.2: pH 2
With
water; caesium carbonate; sodium hydroxide;
In
ethanol; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium ethanolate; ethanol / 0.17 h / 20 °C
1.2: 5 h / 0 - 20 °C
1.3: pH 5
2.1: N,N-dimethyl-formamide; thionyl chloride / 20 °C
2.2: Cooling
3.1: caesium carbonate / acetonitrile / 2 h / 20 °C
4.1: sodium hydroxide; water / ethanol / 2 h / 20 °C
4.2: pH 2
With
thionyl chloride; ethanol; water; sodium ethanolate; caesium carbonate; N,N-dimethyl-formamide; sodium hydroxide;
In
ethanol; acetonitrile;