ethyl 4-chloro-2-pyridin-3-ylpyrimidine-5-carboxylate

Base Information

• Chemical Name: ethyl 4-chloro-2-pyridin-3-ylpyrimidine-5-carboxylate
• CAS No.: 34775-04-7
• Molecular Formula: C₁₂H₁₀ClN₃O₂
• Molecular Weight: 263.683
• Hs Code.: 2933399990
• Mol file: 34775-04-7.mol

Synonyms:4-chloro-2-pyridin-3-yl-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property of ethyl 4-chloro-2-pyridin-3-ylpyrimidine-5-carboxylate

Chemical Property:

• Vapor Pressure: 0.000112mmHg at 25°C
• Boiling Point: 336.5±34.0 °C(Predicted)
• PKA: 2.29±0.12(Predicted)
• Density: 1.313
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 4-chloro-2-(pyridin-3-yl)pyrimidine-5-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 4-chloro-2-pyridin-3-ylpyrimidine-5-carboxylate

There total 4 articles about ethyl 4-chloro-2-pyridin-3-ylpyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-oxo-2-pyridin-3-yl-3,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester (34750-63-5) → 4-chloro-2-pyridin-3-yl-pyrimidine-5-carboxylic acid ethyl ester (34775-04-7)

Guidance literature:

4-oxo-2-pyridin-3-yl-3,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester; With thionyl chloride; N,N-dimethyl-formamide; at 20 ℃;

With potassium carbonate; In water; Cooling;

Reference yield:

3-pyridinecarboximidamide (23255-20-1) → 4-chloro-2-pyridin-3-yl-pyrimidine-5-carboxylic acid ethyl ester (34775-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium ethanolate; ethanol / 0.17 h / 20 °C

1.2: 5 h / 0 - 20 °C

1.3: pH 5

2.1: N,N-dimethyl-formamide; thionyl chloride / 20 °C

2.2: Cooling

With thionyl chloride; ethanol; sodium ethanolate; N,N-dimethyl-formamide;

Reference yield:

diethyl 2-ethoxymethylenemalonate (87-13-8) → 4-chloro-2-pyridin-3-yl-pyrimidine-5-carboxylic acid ethyl ester (34775-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium ethanolate; ethanol / 0.17 h / 20 °C

1.2: 5 h / 0 - 20 °C

1.3: pH 5

2.1: N,N-dimethyl-formamide; thionyl chloride / 20 °C

2.2: Cooling

With thionyl chloride; ethanol; sodium ethanolate; N,N-dimethyl-formamide;

upstream raw materials:

3-pyridinecarboximidamide

diethyl 2-ethoxymethylenemalonate

4-oxo-2-pyridin-3-yl-3,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester

Downstream raw materials:

9-(2-hydroxy-ethyl)-2-pyridin-3-yl-8,9-dihydro-7H-pyrimido[4,5-e][1,4]oxazepin-5-one

4-(3-Cyano-phenoxy)-2-pyridin-3-yl-pyrimidine-5-carboxylic acid ethyl ester

4-(3-Cyano-phenoxy)-2-pyridin-3-yl-pyrimidine-5-carboxylic acid

[4-(3-Cyano-phenoxy)-2-pyridin-3-yl-pyrimidin-5-yl]carbamic acid tert-butyl ester

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