1-(Pyridin-2-yl)cyclohexanecarbonitrile

Base Information

• Chemical Name: 1-(Pyridin-2-yl)cyclohexanecarbonitrile
• CAS No.: 204067-32-3
• Molecular Formula: C₁₂H₁₄N₂
• Molecular Weight: 186.257
• Hs Code.: 2933399090
• Mol file: 204067-32-3.mol

Synonyms:1-(Pyridin-2-yl)cyclohexanecarbonitrile;1-(2-Pyridinyl)cyclohexanecarbonitrile;Cyclohexanecarbonitrile, 1-(2-pyridinyl)-

Chemical Property of 1-(Pyridin-2-yl)cyclohexanecarbonitrile

Chemical Property:

• Boiling Point: 349℃
• Flash Point: 122℃
• PSA: 36.68000
• Density: 1.07
• LogP: 2.80708

Purity/Quality:

98% ^*data from raw suppliers

1-(Pyridin-2-yl)cyclohexanecarbonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Pyridin-2-yl)cyclohexanecarbonitrile

There total 4 articles about 1-(Pyridin-2-yl)cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyridine-2-acetonitrile (2739-97-1) + 1,5-dibromo-pentane (111-24-0) → 1-(pyridin-2-yl)cyclohexanecarbonitrile (204067-32-3)

Guidance literature:

With sodium hydride; In diethyl ether; dimethyl sulfoxide; mineral oil; at 15 - 20 ℃; for 25h; Inert atmosphere;

Reference yield: 99.0%

2-fluoropyridine (372-48-5) + cyclohexane carbonitrile (766-05-2) → 1-(pyridin-2-yl)cyclohexanecarbonitrile (204067-32-3)

Guidance literature:

With potassium hexamethylsilazane; In toluene; at 60 ℃; for 2h;

DOI:10.1002/anie.201600305

Reference yield: 85.0%

2-chloropyridine (109-09-1) + 1-(pyridin-2-ylsulfonyl)cyclohexanecarbonitrile → 1-(pyridin-2-yl)cyclohexanecarbonitrile (204067-32-3)

Guidance literature:

1-(pyridin-2-ylsulfonyl)cyclohexanecarbonitrile; With tri-n-butyllithium magnesate complex; In tetrahydrofuran; hexane; n-heptane; at -15 - -5 ℃; for 0.5h;

2-chloropyridine; In tetrahydrofuran; hexane; n-heptane; at 20 ℃; for 2h;

DOI:10.1002/anie.201704028

upstream raw materials:

pyridine-2-acetonitrile

1,5-dibromo-pentane

2-fluoropyridine

cyclohexane carbonitrile

Refernces

• 1、 Yang, Xun,Nath, Dinesh,Gau, Michael R.,Steward, Omar W.,Fleming, Fraser F.. "Sulfone–Metal Exchange and Alkylation of Sulfonylnitriles". supporting information. p. 7257 - 7260. Retrieved 2017/06/13.
• 2、 Lacivita, Enza,Schepetkin, Igor A.,Stama, Madia L.,Kirpotina, Liliya N.,Colabufo, Nicola A.,Perrone, Roberto,Khlebnikov, Andrei I.,Quinn, Mark T.,Leopoldo, Marcello. "Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2". . p. 3913 - 3924. Retrieved 2015/06/22.