3,5-Dichloro-2-fluoro-4-iodopyridine

Base Information

• Chemical Name: 3,5-Dichloro-2-fluoro-4-iodopyridine
• CAS No.: 406676-24-2
• Molecular Formula: C₅HCl₂FIN
• Molecular Weight: 291.879
• DSSTox Substance ID: DTXSID30573777
• Nikkaji Number: J1.662.520E
• Wikidata: Q82462597
• Mol file: 406676-24-2.mol

Synonyms:3,5-Dichloro-2-fluoro-4-iodopyridine;406676-24-2;C5HCl2FIN;DTXSID30573777;MFCD19688057;AKOS016012734;DS-5350;SY345456;CS-0157874;C75059;A917866

Chemical Property of 3,5-Dichloro-2-fluoro-4-iodopyridine

Chemical Property:

• PSA: 12.89000
• LogP: 3.13210
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 290.85148
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

97% ^*data from raw suppliers

3,5-Dichloro-2-fluoro-4-iodopyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=C(C(=N1)F)Cl)I)Cl

Technology Process of 3,5-Dichloro-2-fluoro-4-iodopyridine

There total 2 articles about 3,5-Dichloro-2-fluoro-4-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-Fluoro-3,5-dichloropyridine (823-56-3) → 3,5-dichloro-2-fluoro-4-iodopyridine (406676-24-2)

Guidance literature:

With iodine; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -75 ℃;

DOI:10.1002/1099-0690(200112)2001:23<4533::AID-EJOC4533>3.0.CO;2-1

Reference yield:

2,3,5-trichloropyridine (16063-70-0) → 3,5-dichloro-2-fluoro-4-iodopyridine (406676-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / KF / tetrahydrothiophene 1,1-dioxide / 20 h / 180 °C

2: 73 percent / lithium diisopropylamide; iodine / tetrahydrofuran; hexane / -75 °C

With potassium fluoride; iodine; lithium diisopropyl amide; In tetrahydrofuran; sulfolane; hexane;

DOI:10.1002/1099-0690(200112)2001:23<4533::AID-EJOC4533>3.0.CO;2-1

Reference yield: 56.0%

3,5-dichloro-2-fluoro-4-iodopyridine (406676-24-2) → 3,5-dichloro-2-fluoro-6-iodopyridine (406676-35-5)

Guidance literature:

With 2,2,6,6-tetramethylpiperidinyl-lithium; water; In tetrahydrofuran; methanol; at -100 - -75 ℃;

DOI:10.1002/1099-0690(200112)2001:23<4533::AID-EJOC4533>3.0.CO;2-1

upstream raw materials:

2-Fluoro-3,5-dichloropyridine

2,3,5-trichloropyridine

Downstream raw materials:

3,5-dichloro-2-fluoro-6-iodopyridine

3,5-dichloro-2-fluoro-6-pyridinecarboxylic acid