823-56-3

Basic information

• Product Name: 2-Fluoro-3,5-dichloropyridine
• Synonyms: 2-FLUORO-3,5-DICHLOROPYRIDINE;3,5-DICHLORO-2-FLUOROPYRIDINE;2-Fluoro-3,5-dichloropyridine,97%;3,5-Dichloro-2-fluoropyridine,98%;3,5-dichloro-6-fluoropyridine;3,5-Dichloro-2-fluoropyridine≥ 99.5% (GC)
• CAS NO: 823-56-3
• Molecular Formula: C₅H₂Cl₂FN
• Molecular Weight: 165.98
• EINECS: 302-396-3
• Product Categories: Pyridine;Chloropyridines;Fluoropyridines;Halopyridines;Fluorine series
• Mol File: 823-56-3.mol

Chemical Properties

• Melting Point: 41-43°C
• Boiling Point: 234.8°C at 760 mmHg
• Flash Point: 93.2°C
• Appearance: /
• Density: 1.226g/cm³
• Vapor Pressure: 0.0519mmHg at 25°C
• Refractive Index: 1.452
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: -1.94±0.10(Predicted)
• BRN: 1365267
• CAS DataBase Reference: 2-Fluoro-3,5-dichloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-3,5-dichloropyridine(823-56-3)
• EPA Substance Registry System: 2-Fluoro-3,5-dichloropyridine(823-56-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22-40
• Safety Statements: 36/37/39-26-22
• Hazardous Substances Data: 823-56-3(Hazardous Substances Data)

Usage

Chemical Properties

Pale yellow crystalline powder

InChI:InChI=1/C10H9F3O2/c1-2-9(14)7-3-5-8(6-4-7)15-10(11,12)13/h3-6H,2H2,1H3

Upstream product

• 16063-70-0 2,3,5-trichloropyridine 
• 23906-97-0 tetra-n-octylphosphonium bromide 

Downstream Products

• 85331-33-5 2-Cyano-3,5-dichloropyridine 
• 915030-88-5 2-(3,5-dichloropyridin-2-yl)cyclopropanecarboxylic acid 
• 1295651-03-4 C₂₆H₂₁Cl₂NO₇ 
• 1295651-02-3 C₂₆H₂₅Cl₂NO₇ 
• 1295651-01-2 C₂₅H₂₃Cl₂NO₇ 
• 1295651-00-1 C₂₄H₂₁Cl₂NO₇ 
• 74267-69-9 C₁₇H₁₃Cl₂NO₄ 
• 1295650-93-9 C₁₇H₁₇Cl₂NO₄ 
• 71283-79-9 C₁₆H₁₅Cl₂NO₄ 
• 71283-63-1 C₁₅H₁₃Cl₂NO₄ 
• 1202503-11-4 ethyl 3-[1-(3,5-dichloropyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl]benzoate 
• 915030-84-1 2-[3,5-dichloro-2-pyridinyl]cyclohexanone 
• 89402-43-7 5-chloro-2,3-difluoropyridine 

Relevant articles and documents

Direct formation of 2,3,5-trichloropyridine and its nucleophilic displacement reactions in ionic liquid

Reaction of trichloroacetaldehyde and acrylonitrile in the presence of a catalytic amount of copper (I) chloride in ionic liquid afforded 2,3,5-trichloropyridine, fluprination of which with KF and CsF in ionic liquid afforded 3,5-dichloro-2-fluoropyridihe and 5-chloro-2,3-dichloropyridine. Reaction of 2,3,5-trichloropyridine, 3,5-dichloro-2-fluoropyridine, or 5-chloro-2,3-dichloropyride with 2-(4-hydroxyphenoxy) propionates in ionic liquid afforded the corresponding 2-aryloxylpropionates in good yields.

Process for the preparation of substituted 2,3-difluoropyridines

The invention relates to a novel process for the preparation of substituted 2,3-difluoropyridines by reaction of substituted 2,3-halopyridines with fluoride salts in the presence of phase transfer catalysts, preferably in polar aprotic solvents, without removing the resulting substituted 2,3-difluoropyridines continuously from the reaction mixture. The substituted 2,3-difluoropyridines which can be prepared according to the invention are, inter alia, starting materials for the preparation of plant protection agents or pharmaceuticals.