2-AMINO-5-BROMO-3-FLUOROBENZOIC ACID

Base Information

• Chemical Name: 2-AMINO-5-BROMO-3-FLUOROBENZOIC ACID
• CAS No.: 874784-14-2
• Molecular Formula: C7H5BrFNO2
• Molecular Weight: 234.025
• Hs Code.: 2922499990
• Mol file: 874784-14-2.mol

Synonyms:BUTTPARK 51\07-22;2-AMINO-5-BROMO-3-FLUOROBENZOIC ACID

Chemical Property of 2-AMINO-5-BROMO-3-FLUOROBENZOIC ACID

Chemical Property:

• Boiling Point: 321.7±42.0 °C(Predicted)
• PKA: 4.21±0.10(Predicted)
• PSA: 63.32000
• Density: 1.877±0.06 g/cm3(Predicted)
• LogP: 2.44980
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%+, ^*data from raw suppliers

2-Amino-5-bromo-3-fluorobenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-BROMO-3-FLUOROBENZOIC ACID

There total 1 articles about 2-AMINO-5-BROMO-3-FLUOROBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-fluoroanthranilic acid (825-22-9) → 2-amino-5-bromo-3-fluorobenzoic acid (874784-14-2)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield: 97.0%

2-amino-5-bromo-3-fluorobenzoic acid (874784-14-2) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 2-amino-5-bromo-3-fluoro-N-methoxy-N-methylbenzamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 16h;

Reference yield: 96.0%

2-amino-5-bromo-3-fluorobenzoic acid (874784-14-2) → (2-amino-5-bromo-3-fluorophenyl)methanol (906811-50-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

upstream raw materials:

3-fluoroanthranilic acid

Downstream raw materials:

(2-amino-5-bromo-3-fluorophenyl)methanol

6-bromo-8-fluoroquinazolin-2-ol

6-bromo-2-chloro-8-fluoroquinazoline

Refernces

• 1、 -. "TREATMENT OF FIBROSIS WITH IRE1 SMALL MOLECULE INHIBITORS". Paragraph 00330. . Retrieved 2020/11/30.
• 2、 -. "NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES". Page/Page column 50. . Retrieved 2020/12/07.