FMOC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4-AMINO-4-CARBOXYLIC ACID

Base Information

• Chemical Name: FMOC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4-AMINO-4-CARBOXYLIC ACID
• CAS No.: 93372-25-9
• Molecular Formula: C25H29N2O5 *
• Molecular Weight: 437.516
• Hs Code.: 2933 39 99
• Mol file: 93372-25-9.mol

Synonyms:FMOC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4-AMINO-4-CARBOXYLIC ACID;FMOC-TOAC

Chemical Property of FMOC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4-AMINO-4-CARBOXYLIC ACID

Chemical Property:

• Melting Point: 162-164°C
• PSA: 82.36000
• LogP: 4.48930
• Storage Temp.: -20°C Freezer
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

≥ 98% (HPLC) ^*data from raw suppliers

Fmoc-2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A protected spin-labelled, cyclic, chiral ?amino acid resolved in an enantiomerically pure state A stable free radical spin label.

Technology Process of FMOC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4-AMINO-4-CARBOXYLIC ACID

There total 4 articles about FMOC-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL-4-AMINO-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + 4-Amino-4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl radical (15871-57-5) → 4-<(9-fluorenylmethyloxycarbonyl)amino>-4-carboxy-2,2,6,6-tetramethylpiperidine-N-oxyl (93372-25-9)

Guidance literature:

With triethylamine; In water; acetonitrile; for 0.5h;

Reference yield:

9-fluorenylmethyl N-succinimidyl carbonate (102774-86-7) + 4-Amino-4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl radical (15871-57-5) → 4-<(9-fluorenylmethyloxycarbonyl)amino>-4-carboxy-2,2,6,6-tetramethylpiperidine-N-oxyl (93372-25-9)

Guidance literature:

With triethylamine; In water; acetonitrile;

Reference yield:

4-oxo-2,2,6,6-tetramethylpiperidin-oxyl (45985-26-0,2896-70-0) → 4-<(9-fluorenylmethyloxycarbonyl)amino>-4-carboxy-2,2,6,6-tetramethylpiperidine-N-oxyl (93372-25-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / aq. ethanol

2: 92 percent / aq. Ba(OH)2 / 48 h / 140 °C

3: Et₃N / acetonitrile; H₂O

With barium dihydroxide; triethylamine; In ethanol; water; acetonitrile;

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

4-Amino-4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl radical

9-fluorenylmethyl N-succinimidyl carbonate

4-oxo-2,2,6,6-tetramethylpiperidin-oxyl