N-Methyl Zonisamide

Base Information

• Chemical Name: N-Methyl Zonisamide
• CAS No.: 68292-02-4
• Molecular Formula: C₉H₁₀N₂O₃S
• Molecular Weight: 226.256
• UNII: 24E57LD622
• ChEMBL ID: CHEMBL3230846
• DSSTox Substance ID: DTXSID40500736
• Wikidata: Q27253844
• Mol file: 68292-02-4.mol

Synonyms:N-Methyl Zonisamide;68292-02-4;1-(1,2-benzoxazol-3-yl)-N-methylmethanesulfonamide;1,2-Benzisoxazole-3-methanesulfonamide, N-methyl-;24E57LD622;UNII-24E57LD622;1-(Benzo[d]isoxazol-3-yl)-N-methylmethanesulfonamide;CHEMBL3230846;SCHEMBL10154282;DTXSID40500736;FT-0672371;Q27253844

Chemical Property of N-Methyl Zonisamide

Chemical Property:

• PSA: 80.58000
• LogP: 2.34870
• Storage Temp.: -20°C, Inert atmosphere
• Solubility.: Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 226.04121336
• Heavy Atom Count: 15
• Complexity: 312

Purity/Quality:

98% ^*data from raw suppliers

N-Methyl Zonisamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNS(=O)(=O)CC1=NOC2=CC=CC=C21
• Uses: A methylated analog of Zonisamide (Z700000) with anticonvulsant activity.

Technology Process of N-Methyl Zonisamide

There total 2 articles about N-Methyl Zonisamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-benzoxazol-3-ylmethanesulfonyl chloride (73101-65-2) + methylamine (74-89-5) → C-benzo[d]isoxazol-3-yl-N-methyl-methanesulfonamide (68292-02-4)

Guidance literature:

In ethyl acetate; Ambient temperature;

DOI:10.1021/jm00188a011

Reference yield:

→ C-benzo[d]isoxazol-3-yl-N-methyl-methanesulfonamide (68292-02-4)

Guidance literature:

1,2-Benzisoxazol-3-methansulfonylchlorid; Methylamin;

upstream raw materials:

1,2-benzoxazol-3-ylmethanesulfonyl chloride

methylamine