N-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide

Base Information

• Chemical Name: N-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide
• CAS No.: 1201788-17-1
• Molecular Formula: C₁₄H₂₂BNO₄S
• Molecular Weight: 311.21
• Mol file: 1201788-17-1.mol

Synonyms:N-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide

Chemical Property of N-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide

There total 2 articles about N-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanesulfonamide (616880-14-9) + methyl iodide (74-88-4) → N-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide (1201788-17-1)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 18h; Inert atmosphere;

Reference yield: 9.0%

N-(4-bromophenyl)-N-methylmethanesulfonamide (99980-38-8) + bis(pinacol)diborane (73183-34-3) → N-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide (1201788-17-1)

Guidance literature:

N-(4-bromophenyl)-N-methylmethanesulfonamide; bis(pinacol)diborane; With potassium acetate; In 1,4-dioxane; for 0.166667h; Inert atmosphere;

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 90 ℃; for 16h;

Reference yield:

N-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide (1201788-17-1) + 3-fluoro-4-iodo-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine (1201787-18-9) → N-{-4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]phenyl}-N-methylmethanesulfonamide (1201788-16-0)

Guidance literature:

With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 125 ℃; for 1h; Microwave irradiation; Sealed tube;

upstream raw materials:

N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanesulfonamide

methyl iodide

N-(4-bromophenyl)-N-methylmethanesulfonamide

bis(pinacol)diborane

Downstream raw materials:

N-{-4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]phenyl}-N-methylmethanesulfonamide