Technology Process of Pyrido(3',2':4,5)thieno(3,2-d)pyrimidin-4(3H)-one, 9-(dimethylamino)-3-(hexahydro-1H-azepin-1-yl)-
There total 6 articles about Pyrido(3',2':4,5)thieno(3,2-d)pyrimidin-4(3H)-one, 9-(dimethylamino)-3-(hexahydro-1H-azepin-1-yl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
toluene;
at 130 ℃;
DOI:10.1021/jm0504407
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 99 percent / 5 h / Heating
2: 45 percent / p-TsOH / toluene
With
toluene-4-sulfonic acid;
In
toluene;
DOI:10.1016/j.bmcl.2006.06.053
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 93 percent / 1.33 h / 100 °C
2.1: 98 percent / HCl(gas) / methanol / 10 h / 0 °C
3.1: NaH / tetrahydrofuran / 0 °C
3.2: tetrahydrofuran / 24 h / 20 °C
3.3: 85 percent / NaH / tetrahydrofuran / 1.83 h / Heating
4.1: 99 percent / ethanol / 4.5 h / Heating
5.1: 45 percent / p-toluenesulfonic acid / toluene / 130 °C
With
hydrogenchloride; sodium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; ethanol; toluene;
DOI:10.1021/jm0504407
