14164-26-2Relevant articles and documents
ANTAGONISTS OF THE MGLU RECEPTOR AND USES THEREOF
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Page/Page column 30, (2008/06/13)
The present invention discloses compounds of general formula (I) wherein X1-X4 and R1-R3 are as defined in the description. The present invention also discloses methods of treatment for pain, neurodegeneration and convulsive states in a host mammal in need thereof, and pharmaceutical compositions including those compounds.
Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists
Zheng, Guo Zhu,Bhatia, Pramila,Daanen, Jerome,Kolasa, Teodozyj,Patel, Meena,Latshaw, Steven,El Kouhen, Odile F.,Chang, Renjie,Uchic, Marie E.,Miller, Loan,Nakane, Masaki,Lehto, Sonya G.,Honore, Marie P.,Moreland, Robert B.,Brioni, Jorge D.,Stewart, Andrew O.
, p. 7374 - 7388 (2007/10/03)
SAR (structure-activity relationship) studies of triazafluorenone derivatives as potent mGluR1 antagonists are described. The triazafluorenone derivatives are non-amino acid derivatives and noncompetitive mGluR1 antagonists that bind at a putative alloste
NEW ONE-POT SYNTHESIS OF ENAMINEDINITRILES
Berry, Robert W. H.,Drewry, Peter C.,Hodson, Harold F.
, p. 958 - 975 (2007/10/02)
A convenient procedure is reported for the one-pot preparation of enaminedinitriles.This involves the sodium methoxide-catalysed addition of methanol to a suitably substituted nitrile followed by reaction of the resulting imidate with malononitrile.The mechanism, scope and limitations of the synthesis have been investigated.Spectroscopic evidence is presented that the products exist in the enaminedinitrile rather than in the tautomeric imino form.Various reactions of the compounds including halogen exchange, anion formation and amine displacement have been studied and used to extend the range of enaminedinitriles prepared.
Reactions retrodieniques - XVIII. Synthese par thermolyse eclair et etude d'allenes fonctionnels reactifs
Hakiki, Abdelhak,Ripoll, Jean-Louis,Thuillier, Andre
, p. 911 - 920 (2007/10/02)
The flash thermolysis of anthracenic Diels-Alder adducts leads to the obtention and low temperature spectroscopic characterization (ir, 1H and 13C nmr) of allenes 1-11 (see table 1).Butadienal 1, the simplest α-allenic aldehyde, is thus obtained from its precursors 13, 14 or 17.Thermolysis of the intermediate allylic alcohol 15 gives buta-1,3-dien-2-ol 18, which tautomerizes to methylvinylketone even at -100 deg C.An attempted synthesis of a natural δ-allenic ester, methyl laballenate 19, was undertaken using this method; however, the thermolysis of ester 24 leads via 19 to methyl acrylate and (Z + E) pentadeca-1,3-diene 25, resulting formally from a retroene cleavage of 19.Thermolyses of related esters 26 and 27 give in the same way the corresponding 1,3-dienes.Allenes with gem electron attracting groups are very reactive compounds acting as ketene equivalents in nucleophilic additions and or dipolar cycloadditions.The thermolysis of adducts 28-32, obtained by Knoevenagel condensation of malonic derivatives with ketone 16, leads to the following allenes of this series: 1,1-dicyano-1-methoxycarbonyl propadiene 4, 1,1-bis-(ethoxycarbonyl) propadiene 5 and 1,1-bis-(methoxycarbonyl) propadiene 6.Yields and purity are lower in the case of 3 and 5, owing to the presence of the thermolabile ethoxycarbonyl groups.The possibility of performing nucleophilic additions to the most polymerizable of these allenes: 1,1-dicyanopropadiene 2, is demonstrated by its clean, good yield additions at -50 deg C with methanol, methyl lithium, aniline ir dimethylamine.Allenes O or N-substituted on the allenic carbon are often reactive substances and are known mainly in the case of alkyl ethers and tertiary amines.The flash thermolysis of allylic alcohol 38 gives in good yield propanediol 7 which tautomerizes into acrolein at -50 deg C.Trimethylsilyloxypropadiene 8, 1-trimethylsilyloxybuta-1,2-diene 9 and 3-trimethylsilyloxybuta-1,2-diene 10 could also be obtained from their precursors 40, 44-46.Thermolysis of amine 49 leads in the same way to propadienamine 11, a reactive enamine postulated as a cosmic species and tautomerizing at -65 deg C into 1-azabuta-1,3-diene 50.
REACTION OF DIMETHYLFORMAMIDE AND DIMETHYLACETAMIDE DIETHYL ACETALS WITH MALONONITRILE
Granik, V. G.,Grizik, S. I.,Solov'eva, N. P.,Anisimova, O. S.,Sheinker, Yu. N.
, p. 613 - 617 (2007/10/02)
In the reaction of N,N-dimethylacetamide diethyl acetal with malononitrile the dimethylammonium salt (or the N, N, N', N'-tetramethylacetamidinium salt with an excess of the acetal) of 2-methyl-1,1,3,3-propenetetracarbonitrile was obtained in addition to α-cyano-β-dimethylaminocrotononitrile.Its structure was proved by 1H and 13C NMR spectroscopy and mass spectrometry and also by its conversion into 2-chloro-4-methyl-3,5-dicyano-6-aminopyridine.The reaction of dimethylformamide diethyl acetal with malononitrile takes place similarly.
