3-(bromomethyl)-2-fluoropyridine

Base Information

• Chemical Name: 3-(bromomethyl)-2-fluoropyridine
• CAS No.: 30412-42-1
• Molecular Formula: C6H5BrFN
• Molecular Weight: 190.0130032
• Mol file: 30412-42-1.mol

Synonyms:3-(bromomethyl)-2-fluoropyridine

Chemical Property of 3-(bromomethyl)-2-fluoropyridine

Chemical Property:

• PSA: 12.89000
• LogP: 2.11560
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99.00% ^*data from raw suppliers

3-(bromomethyl)-2-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(bromomethyl)-2-fluoropyridine

There total 3 articles about 3-(bromomethyl)-2-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-fluoro-3-(hydroxymethyl)pyridine (131747-55-2) → 3-(bromomethyl)-2-fluoropyridine (30412-42-1)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; Inert atmosphere; Cooling with ice;

Reference yield: 61.0%

2-fluoro-3-methylpyridine (2369-18-8) → 3-(bromomethyl)-2-fluoropyridine (30412-42-1)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 18h; Reflux;

Reference yield:

→ 3-(bromomethyl)-2-fluoropyridine (30412-42-1)

Guidance literature:

2-Fluor-3-methyl-pyridin, N-Bromsuccinimid, wenig Dibenzoylperoxid, sd. Tetrachlormethan;

DOI:10.1021/jm00285a008

upstream raw materials:

2-fluoro-3-methylpyridine

2-fluoro-3-(hydroxymethyl)pyridine

Downstream raw materials:

(S)-3-(2-fluoropyridin-3-yl)-2-phenylpropanoic acid

Refernces

• 1、 -. "MACROCYCLES AS PDE1 INHIBITORS". Paragraph 0280; 0281. . Retrieved 2019/06/30.
• 2、 -. "NOVEL ANTIVIRAL PYRROLOPYRIDINE DERIVATIVE AND A PRODUCTION METHOD FOR SAME". Paragraph 0468; 0469; 0470. . Retrieved 2014/12/09.