5-Quinoxalinecarbonitrile, 7-amino-1,2,3,4-tetrahydro-6-methyl-2,3-dioxo- (9CI)

Base Information

• Chemical Name: 5-Quinoxalinecarbonitrile, 7-amino-1,2,3,4-tetrahydro-6-methyl-2,3-dioxo- (9CI)
• CAS No.: 648957-94-2
• Molecular Formula: C₁₀H₈N₄O₂
• Molecular Weight: 216.199
• Mol file: 648957-94-2.mol

Synonyms:5-Quinoxalinecarbonitrile, 7-amino-1,2,3,4-tetrahydro-6-methyl-2,3-dioxo- (9CI)

Chemical Property of 5-Quinoxalinecarbonitrile, 7-amino-1,2,3,4-tetrahydro-6-methyl-2,3-dioxo- (9CI)

Chemical Property:

Purity/Quality:

7-amino-1,2,3,4-tetrahydro-6-methyl-2,3-dioxo-5-Quinoxalinecarbonitrile 97.00% ^*data from reagent suppliers

Safty Information:

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Technology Process of 5-Quinoxalinecarbonitrile, 7-amino-1,2,3,4-tetrahydro-6-methyl-2,3-dioxo- (9CI)

There total 5 articles about 5-Quinoxalinecarbonitrile, 7-amino-1,2,3,4-tetrahydro-6-methyl-2,3-dioxo- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

6-methyl-7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-5-carbonitrile (573692-39-4) → 7-amino-6-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-5-carbonitrile (648957-94-2)

Guidance literature:

With tin(ll) chloride; In ethanol; for 20h; Heating;

DOI:10.1016/S0968-0896(03)00059-2

Reference yield:

2-chloro-6-methyl-benzonitrile (6575-09-3) → 7-amino-6-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-5-carbonitrile (648957-94-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.61 g / fuming HNO₃; CF₃CO₂H / 20 - 60 °C

2: dimethylformamide / 18 h / 70 °C

3: 149 mg / SnCl₂*2H₂O / ethanol / 2 h / Heating

4: 57 percent / fuming HNO₃; CF₃CO₂H / 2 h / 20 °C

5: 94 percent / SnCl₂*2H₂O / ethanol / 20 h / Heating

With nitric acid; trifluoroacetic acid; tin(ll) chloride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(03)00059-2

Reference yield:

2-chloro-6-methyl-3-nitrobenzonitrile (74671-11-7) → 7-amino-6-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-5-carbonitrile (648957-94-2)

Guidance literature:

Multi-step reaction with 4 steps

1: dimethylformamide / 18 h / 70 °C

2: 149 mg / SnCl₂*2H₂O / ethanol / 2 h / Heating

3: 57 percent / fuming HNO₃; CF₃CO₂H / 2 h / 20 °C

4: 94 percent / SnCl₂*2H₂O / ethanol / 20 h / Heating

With nitric acid; trifluoroacetic acid; tin(ll) chloride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(03)00059-2

upstream raw materials:

6-methyl-7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-5-carbonitrile

2-chloro-6-methyl-benzonitrile

2-chloro-6-methyl-3-nitrobenzonitrile

6-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carbonitrile

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