6-Chloro-4-methoxypyridine-3-carbaldehyde

Base Information

• Chemical Name: 6-Chloro-4-methoxypyridine-3-carbaldehyde
• CAS No.: 1256823-05-8
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.58104
• Hs Code.: 2933399090
• Mol file: 1256823-05-8.mol

Synonyms:6-Chloro-4-methoxypyridine-3-carbaldehyde;6-Chloro-4-methoxynicotinaldehyde

Chemical Property of 6-Chloro-4-methoxypyridine-3-carbaldehyde

Chemical Property:

• Boiling Point: 301.9±37.0 °C(Predicted)
• PKA: 0.26±0.10(Predicted)
• PSA: 39.19000
• Density: 1.317±0.06 g/cm3(Predicted)
• LogP: 1.55610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-4-methoxypyridine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-4-methoxypyridine-3-carbaldehyde

There total 11 articles about 6-Chloro-4-methoxypyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(6-chloro-4-methoxypyridin-3-yl)methanol (1263059-66-0) → 6-chloro-4-methoxypyridine-3-carbaldehyde (1256823-05-8)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 17 - 25 ℃; for 1h; Inert atmosphere;

Reference yield: 65.0%

5-bromo-2-chloro-4-methoxypyridine (880870-13-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-chloro-4-methoxypyridine-3-carbaldehyde (1256823-05-8)

Guidance literature:

5-bromo-2-chloro-4-methoxypyridine; With n-butyllithium; at -60 ℃; for 0.0833333h;

N,N-dimethyl-formamide; at -60 ℃; for 0.166667h;

Reference yield: 63.2%

→ 6-chloro-4-methoxypyridine-3-carbaldehyde (1256823-05-8)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere;

upstream raw materials:

methyl 6-chloro-4-methoxypyridine-3-carboxylate

(6-chloro-4-methoxypyridin-3-yl)methanol

3-oxopentanedioic acid dimethyl ester

methyl 4,6-dihydroxypyridine-3-carboxylate

Downstream raw materials:

C₁₃H₁₀ClNO₂

C₁₆H₁₇ClN₂O

C₁₆H₁₅ClN₄O

C₁₆H₁₆ClNO₂