4-tert-Butyl-1,2-dimethylcyclohexanol

Base Information

• Chemical Name: 4-tert-Butyl-1,2-dimethylcyclohexanol
• CAS No.: 32383-56-5
• Molecular Formula: C₁₂H₂₄O
• Molecular Weight: 184.322
• Mol file: 32383-56-5.mol

Synonyms:4-tert-Butyl-1,2-dimethylcyclohexanol

Chemical Property of 4-tert-Butyl-1,2-dimethylcyclohexanol

Chemical Property:

• Boiling Point: 226.9±8.0 °C(Predicted)
• PKA: 15.41±0.60(Predicted)
• PSA: 20.23000
• Density: 0.885±0.06 g/cm3(Predicted)
• LogP: 3.21970

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-tert-Butyl-1,2-dimethylcyclohexanol

There total 9 articles about 4-tert-Butyl-1,2-dimethylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-tert-butylcyclohexanone dimethylhydrazone (58911-63-0) → 1-methyl-cis-2-methyl-trans-4-t-butylcyclohexanol (32383-54-3,32383-55-4,32383-56-5,32383-57-6,80452-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) lithium di-isopropylamide (LDA) / 1.) hexane/THF, 3 h, 0 deg C, 2.) hexane/THF, -78 deg C -> room temperature

2: copper(II) chloride, water / tetrahydrofuran / 4 h / 0 °C

3: diethyl ether / 3 h / 0 °C

With water; copper dichloride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;

DOI:10.1039/P29890000747

Reference yield:

4-tert-butylcyclohexanone dimethylhydrazone (58911-63-0) → 1-methyl-trans-2-methyl-cis-4-t-butylcyclohexanol (32383-54-3,32383-55-4,32383-56-5,32383-57-6,80452-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) lithium di-isopropylamide (LDA) / 1.) hexane/THF, 3 h, 0 deg C, 2.) hexane/THF, -78 deg C -> room temperature

2: copper(II) chloride, water / tetrahydrofuran / 4 h / 0 °C

3: diethyl ether / 3 h / 0 °C

With water; copper dichloride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;

DOI:10.1039/P29890000747

Reference yield:

trans-4-tert-Butyl-2-methyl-cyclohexanone-N,N-dimethylhydrazone (58911-80-1,67009-19-2,67009-20-5,67009-21-6,85114-30-3,114128-98-2,58911-72-1) → 1-methyl-trans-2-methyl-cis-4-t-butylcyclohexanol (32383-54-3,32383-55-4,32383-56-5,32383-57-6,80452-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(II) chloride, water / tetrahydrofuran / 4 h / 0 °C

2: diethyl ether / 3 h / 0 °C

With water; copper dichloride; In tetrahydrofuran; diethyl ether;

DOI:10.1039/P29890000747

upstream raw materials:

methyl magnesium iodide

4-tert-butyl-2-methylcyclohexanone

methyllithium

4-tert-butylcyclohexanone dimethylhydrazone

Refernces