N-(4-Hydroxypyridin-3-yl)acetamide

Base Information

• Chemical Name: N-(4-Hydroxypyridin-3-yl)acetamide
• CAS No.: 101860-99-5
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.153
• Hs Code.: 2933399090
• Mol file: 101860-99-5.mol

Synonyms:N-(4-Hydroxypyridin-3-yl)acetamide

Chemical Property of N-(4-Hydroxypyridin-3-yl)acetamide

Chemical Property:

• PSA: 62.22000
• LogP: 0.81860

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-Hydroxypyridin-3-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-Hydroxypyridin-3-yl)acetamide

There total 2 articles about N-(4-Hydroxypyridin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

3-aminopyridin-4-ol (6320-39-4) + acetyl chloride (75-36-5) → N-(4-hydroxy-[3]pyridyl)-acetamide (101860-99-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h; Heating / reflux;

Reference yield:

3-aminopyridin-4-ol (6320-39-4) + acetic anhydride (108-24-7) → N-(4-hydroxy-[3]pyridyl)-acetamide (101860-99-5)

Guidance literature:

Reference yield: 78.0%

N-(4-hydroxy-[3]pyridyl)-acetamide (101860-99-5) → 2-methylthiazolo[4,5-c]pyridine (89786-57-2)

Guidance literature:

With pyridine; phosphorus pentasulfide; for 2h; Heating / reflux;

upstream raw materials:

3-aminopyridin-4-ol

acetic anhydride

acetyl chloride

Downstream raw materials:

2-methylthiazolo[4,5-c]pyridine

Refernces