89786-57-2

Upstream product

• 38240-31-2 3-nitro-1H-pyridine-4-thione 
• 108-24-7 acetic anhydride 
• 20511-15-3 3-amino-4-chloropyridine 
• 926-67-0 O-Ethyl thioacetate 
• 18504-84-2 3,3'-dinitro-4,4'-dipyridinyl disulfide 
• 64-19-7 acetic acid 
• 89002-13-1 3-amino-4-mercaptopyridine 
• 101860-99-5 N-(4-hydroxy-[3]pyridyl)-acetamide 
• 139460-11-0 3-amino-4-mercaptopyridine hydrochloride 
• 141-78-6 ethyl acetate 
• 13091-23-1 4-chloro-3-nitropyridine 

Downstream Products

• 273-75-6 thiazolo[4,5-c]pyridine 

Relevant academic research and scientific papers

Novel methods to functionalize thiazolo[4,5-c]pyridines

Novel substituted thiazole[4,5-c]pyridines have been synthesized in good yields from unsubstituted thiazole[4,5-c]pyridine using direct C-H coupling reactions and N-oxide rearrangement chemistry.

Thiazole[4,5-C]pyridine derivatives

The invention relates to compounds of general formula I: wherein R1, R2 and R3 are as defined in the description such compounds are metabotropic glutamate receptor antagonists and are useful in the treatment or prevention of mGluR5 receptor mediated disorders.

Azole antifungal agents, processes for the preparation thereof, and intermediates

A compound represented by the general formula: wherein R1 and R2 denote a halogen atom or hydrogen atoms; R3 means a hydrogen atoms or lower alkyl group; r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic rings, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for -S-, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.

Antifungal agents, and compositions

A compound represented by the general formula: STR1 wherein R1 and R2 denote a halogen atom or hydrogen atom; R3 means a hydrogen atom or lower alkyl group; l, r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic ring, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for --S--, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.

Nouvelle methode de synthese de thiazolopyridines

It has been established that the direct condensation between aromatic and aliphatic thioesters and the variously generated anion of aminochloropyridines represents the best method for the synthesis of thiazolopyridines.The transient thioamides, sometimes isolated, can be easily converted chemically or photochemically into the desired fused heterocycles.