ethyl 4-(2-chloroethyl)piperidine-4-carboxylate hydrochloride

Base Information

• Chemical Name: ethyl 4-(2-chloroethyl)piperidine-4-carboxylate hydrochloride
• CAS No.: 1276088-72-2
• Molecular Formula: C10H19Cl2NO2
• Molecular Weight: 256.16936
• Mol file: 1276088-72-2.mol

Synonyms:ethyl 4-(2-chloroethyl)piperidine-4-carboxylate hydrochloride

Chemical Property of ethyl 4-(2-chloroethyl)piperidine-4-carboxylate hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 2.67900

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(2-chloroethyl)piperidine-4-carboxylate hydrochloride

There total 2 articles about ethyl 4-(2-chloroethyl)piperidine-4-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-tert-butyl 4-ethyl 4-(2-chloroethyl)piperidine-1,4-dicarboxylate (212782-43-9) → ethyl-4-(2-chloroethyl)-piperidine-4-carboxylate hydrochloride (1276088-72-2)

Guidance literature:

hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate (142851-03-4) → ethyl-4-(2-chloroethyl)-piperidine-4-carboxylate hydrochloride (1276088-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With lithium hexamethyldisilazane; hydrogenchloride; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

ethyl-4-(2-chloroethyl)-piperidine-4-carboxylate hydrochloride (1276088-72-2) → azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester (22766-68-3)

Guidance literature:

With potassium carbonate; In toluene; for 1h; Reflux;

upstream raw materials:

1-tert-butyl 4-ethyl 4-(2-chloroethyl)piperidine-1,4-dicarboxylate

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

Downstream raw materials:

azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester

Refernces