N-Methyl-1-(1-methylpiperidin-3-yl)methanamine

Base Information

• Chemical Name: N-Methyl-1-(1-methylpiperidin-3-yl)methanamine
• CAS No.: 639078-61-8
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.244
• Hs Code.: 2933399090
• European Community (EC) Number: 831-947-5
• DSSTox Substance ID: DTXSID80586317
• Mol file: 639078-61-8.mol

Synonyms:639078-61-8;N-Methyl-1-(1-methylpiperidin-3-yl)methanamine;Methyl-(1-methyl-piperidin-3-ylmethyl)-amine;methyl[(1-methylpiperidin-3-yl)methyl]amine;3-Piperidinemethanamine,N,1-dimethyl-(9CI);SCHEMBL2885366;DTXSID80586317;OUBNEVZXIXKNJE-UHFFFAOYSA-N;MFCD05864531;AKOS003237479;AKOS016341118;MCULE-2023816384;SB41749;3-(Methylaminomethyl)-1-methylpiperidine;AM101066;BS-38219;DB-073409;EN300-78458;N-Methyl-1-(1-methyl-3-piperidinyl)methanamine;N-Methyl-(1-methylpiperid-3-yl)methylamine, AldrichCPR;Z763765496

Chemical Property of N-Methyl-1-(1-methylpiperidin-3-yl)methanamine

Chemical Property:

• Vapor Pressure: 1.35mmHg at 25°C
• Boiling Point: 172.141°C at 760 mmHg
• PKA: 10.40±0.10(Predicted)
• Flash Point: 45.982°C
• PSA: 15.27000
• Density: 0.868g/cm³
• LogP: 0.87640
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 142.146998583
• Heavy Atom Count: 10
• Complexity: 93.3

Purity/Quality:

97% ^*data from raw suppliers

N-methyl-1-(1-methylpiperidin-3-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCC1CCCN(C1)C

Technology Process of N-Methyl-1-(1-methylpiperidin-3-yl)methanamine

There total 1 articles about N-Methyl-1-(1-methylpiperidin-3-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(chloromethyl)-1-methylpiperidine (52694-50-5) + methylamine (74-89-5) → N-methyl-1-(1-methylpiperidin-3-yl)methanamine (639078-61-8)

Guidance literature:

In ethanol; at 100 ℃; for 17h;

Reference yield:

[3-cyclohexyl-6-(methoxycarbonyl)-2-phenyl-1H-indol-1-yl]acetic acid (774213-85-3) + N-methyl-1-(1-methylpiperidin-3-yl)methanamine (639078-61-8) → 3-cyclohexyl-1-{[methyl-(1-methyl-piperidin-3-ylmethyl)-carbamoyl]-methyl}-2-phenyl-1H-indole-6-carboxylic acid methyl ester

Guidance literature:

With PS-carbodiimide resin; In dichloromethane; for 24h;

DOI:10.1021/jm050056+

Reference yield:

N-methyl-1-(1-methylpiperidin-3-yl)methanamine (639078-61-8) → 3-cyclopentyl-1-{[methyl-(1-methyl-piperidin-3-ylmethyl)-carbamoyl]-methyl}-2-phenyl-1H-indole-6-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: PS-carbodiimide resin / CH₂Cl₂ / 24 h

2: BBr₃ / CH₂Cl₂ / 0.33 h

With PS-carbodiimide resin; boron tribromide; In dichloromethane;

DOI:10.1021/jm050056+

upstream raw materials:

3-(chloromethyl)-1-methylpiperidine

methylamine

Downstream raw materials:

3-cyclohexyl-1-{[methyl-(1-methyl-piperidin-3-ylmethyl)-carbamoyl]-methyl}-2-phenyl-1H-indole-6-carboxylic acid

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