Mebanazine

Base Information

• Chemical Name: Mebanazine
• CAS No.: 65-64-5
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.197
• Hs Code.: 2928000090
• European Community (EC) Number: 200-615-6
• UNII: Z5R55CJ4CG
• DSSTox Substance ID: DTXSID50859848
• Nikkaji Number: J4.839I
• Wikipedia: Mebanazine
• Wikidata: Q10950142
• NCI Thesaurus Code: C80969
• Pharos Ligand ID: 3WJ25WYWR6HJ
• Metabolomics Workbench ID: 152280
• ChEMBL ID: CHEMBL1909283
• Mol file: 65-64-5.mol

Synonyms:(alpha-methylbenzyl)hydrazine;Actomol;mebanazine;mebanazine monohydrochloride, (R)-isomer;mebanazine monooxalate;mebanazine monooxalate, (S)-isomer;mebanazine monosulfate;mebanazine oxalate;mebanazine oxalate, (+-)-isomer;mebanazine sulfate;mebanazine, (+-)-isomer;mebanazine, (R)-isomer;mebanazine, (S)-isomer

Chemical Property of Mebanazine

Chemical Property:

• Vapor Pressure: 0.0111mmHg at 25°C
• Refractive Index: 1.5436
• Boiling Point: 262.1°C at 760 mmHg
• Flash Point: 129.6°C
• PSA: 38.05000
• Density: 1.005g/cm³
• LogP: 2.30210
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 136.100048391
• Heavy Atom Count: 10
• Complexity: 87.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Phenylethylhydrazine(Mebanazine) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)NN

Technology Process of Mebanazine

There total 17 articles about Mebanazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1-chloroethyl)benzene (672-65-1) → (1-phenyl-ethyl)-hydrazine (24292-42-0,54422-98-9,60325-13-5,65-64-5)

Guidance literature:

With hydrazine hydrate; at 140 ℃; for 18h;

Reference yield: 76.0%

(1-phenylethylidene)hydrazine (13466-30-3) → (1-phenyl-ethyl)-hydrazine (24292-42-0,54422-98-9,60325-13-5,65-64-5)

Guidance literature:

(1-phenylethylidene)hydrazine; In methanol; at 20 ℃;

With sodium tetrahydroborate; sodium hydroxide; In methanol; water; at 40 - 60 ℃; for 1.66667h;

DOI:10.1080/00397911.2011.562063

Reference yield:

(1-bromoethyl)benzne (585-71-7,38661-81-3) → (1-phenyl-ethyl)-hydrazine (24292-42-0,54422-98-9,60325-13-5,65-64-5)

Guidance literature:

With hydrazine; for 0.5h; Yield given;

DOI:10.1002/anie.199702371

upstream raw materials:

(1-chloroethyl)benzene

acetophenone

(1-phenylethylidene)hydrazine

1-(α-Methyl-benzyl)-2-ethoxycarbonyl-hydrazin

Downstream raw materials:

N’-(1-phenylethyl)acetohydrazide

C₁₈H₂₂N₂O₂

(-)-(S)-1,1'-Diphenyl-1-methyl-azomethan

rac.-N-Benzyl-N'-<1-phenyl-aethyl>-hydrazin

Refernces

• 1、 Yang, Yihua,Liu, Shouxin,Li, Junzhang,Tian, Xia,Zhen, Xiaoli,Han, Jianrong. "Convenient method for reduction of C-N double bonds in oximes, imines, and hydrazones using sodium Borohydride-Raney ni system". experimental part. p. 2540 - 2554. Retrieved 2012/07/27.
• 2、 -. "Tetrahydro-indazole cannabinoid modulators". Page/Page column 100-102. . Retrieved 2008/06/13.