5-broMo-2-isopropylbenzaldehyde

Base Information

• Chemical Name: 5-broMo-2-isopropylbenzaldehyde
• CAS No.: 1289039-15-1
• Molecular Formula: C10H11BrO
• Molecular Weight: 227.101
• Mol file: 1289039-15-1.mol

Synonyms:5-broMo-2-isopropylbenzaldehyde

Chemical Property of 5-broMo-2-isopropylbenzaldehyde

Chemical Property:

• PSA: 17.07000
• LogP: 3.38500

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-broMo-2-isopropylbenzaldehyde

There total 2 articles about 5-broMo-2-isopropylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-isopropylbenzaldehyde (6502-22-3) → 5-bromo-2-isopropyl benzaldehyde (1289039-15-1)

Guidance literature:

With aluminum (III) chloride; bromine; In dichloromethane; at 0 - 20 ℃; Product distribution / selectivity;

Reference yield:

1-bromo-2-isopropylbenzene (7073-94-1) → 5-bromo-2-isopropyl benzaldehyde (1289039-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C

1.2: 0.75 h / -78 - 0 °C

2.1: bromine; aluminum (III) chloride / dichloromethane / 0 - 20 °C

With aluminum (III) chloride; n-butyllithium; bromine; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

N-benzyl-7-bromo-1,2,3,4-tetrahydroquinoline (1241912-49-1) + 5-bromo-2-isopropyl benzaldehyde (1289039-15-1) → (1-benzyl-1,2,3,4-tetrahydro-quinolin-7-yl)-(5-bromo-2-isopropyl-phenyl)-methanol (1291094-89-7)

Guidance literature:

N-benzyl-7-bromo-1,2,3,4-tetrahydroquinoline; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

5-bromo-2-isopropyl benzaldehyde; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 0.75h;

With water; ammonium chloride; In tetrahydrofuran; hexane;

upstream raw materials:

1-bromo-2-isopropylbenzene

2-isopropylbenzaldehyde

Downstream raw materials:

4-benzyl-6-(5-bromo-2-isopropyl-benzyl)-3,4-dihydro-2H-benzo[1,4]oxazine

(3R,4S,5S,6R)-2-[3-(4-benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-4-isopropyl-phenyl]-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol

(2S,3R,4R,5S,6R)-2-[3-(3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-4-isopropyl-phenyl]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

(2S,3R,4R,5S,6R)-2-[3-(4-benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-4-isopropyl-phenyl]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

Refernces

• 1、 -. "Glycoside Derivatives and Uses Thereof". . . Retrieved 2011/08/02.