1241912-49-1Relevant articles and documents
Photoactivatable Fluorophore for Stimulated Emission Depletion (STED) Microscopy and Bioconjugation Technique for Hydrophobic Labels
Weber, Michael,Khan, Taukeer A.,Patalag, Lukas J.,Bossi, Mariano,Leutenegger, Marcel,Belov, Vladimir N.,Hell, Stefan W.
, p. 451 - 458 (2021)
The use of photoactivatable dyes in STED microscopy has so far been limited by two-photon activation through the STED beam and by the fact that photoactivatable dyes are poorly solvable in water. Herein, we report ONB-2SiR, a fluorophore that can be both
GLYCOSIDE DERIVATIVES AND USES THEREOF
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Page/Page column 143, (2011/05/06)
This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment
A versatile route to red-emitting carbopyronine dyes for optical microscopy and nanoscopy
Kolmakov, Kirill,Belov, Vladimir N.,Wurm, Christian A.,Harke, Benjamin,Leutenegger, Marcel,Eggeling, Christian,Hell, Stefan W.
experimental part, p. 3593 - 3610 (2010/11/18)
Biological microscopy favors photostable fluorescent markers with large fluorescence quantum yields, low dark triplet state population, good biocompatibility and absorption and emission maxima in the near-infrared, where cellular autofluorescence is minimized. In the present study, carbopyronines absorbing around 640 nm and emitting at around 660 nm, with a low intersystem crossing rate (kisc ≈ 0.5×106 s-1) and excellent properties for cellular imaging were synthesized. A general synthetic route to carbopyronines with functional groups variable in the final steps of the synthesis or in the resulting fluorescent dye is presented. Possessing two 2-me-thoxyethyl groups, the parent dye is soluble in water and most organic solvents. Demethylation of the dye or its precursors is straightforward, clean, and furnishes compounds with one or two 2-hydroxyethyl groups, which can be used for further transformations. Modifications in the linker-containing carboxy group are also possible. A multistep synthesis of the dye starting from a simple precursor and utilizing a single temporary protective group is described. The presented approach may be further applied to the design of caged carbopyronines.