3-Pyridinecarboxylic acid, 2-fluoro-6-Methoxy-

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 2-fluoro-6-Methoxy-
CAS No.:1211515-88-6
Molecular Formula:C7H6FNO3
Molecular Weight:171.1258432
Hs Code.:
Mol file:1211515-88-6.mol

Synonyms:3-Pyridinecarboxylic acid, 2-fluoro-6-Methoxy-;2-Fluoro-6-methoxy-3-pyridinecarboxylic acid;2-fluoro-6-methoxynicotinic acid

Suppliers and Price of 3-Pyridinecarboxylic acid, 2-fluoro-6-Methoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Fluoro-6-methoxypyridine-3-carboxylicAcid
5mg
$ 65.00

Alichem
2-Fluoro-6-methoxynicotinicacid
1g
$ 1797.60

Alichem
2-Fluoro-6-methoxynicotinicacid
250mg
$ 707.20

AK Scientific
2-Fluoro-6-methoxynicotinicacid
50mg
$ 440.00

AK Scientific
2-Fluoro-6-methoxynicotinicacid
10mg
$ 270.00

Total 4 raw suppliers

Chemical Property of 3-Pyridinecarboxylic acid, 2-fluoro-6-Methoxy-

Chemical Property:

Boiling Point:272.4±35.0 °C(Predicted)
PKA:2.81±0.10(Predicted)
PSA：59.42000
Density:1.386±0.06 g/cm3(Predicted)
LogP:0.92750

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

2-Fluoro-6-methoxypyridine-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 2-fluoro-6-Methoxy-

There total 5 articles about 3-Pyridinecarboxylic acid, 2-fluoro-6-Methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117671-02-0
methyl 2,6-difluoro-3-pyridinecarboxylate

: 1211515-88-6
2-fluoro-6-methoxypyridine-3-carboxylic acid

Guidance literature:: With sodium methylate; In tetrahydrofuran; methanol;

Reference yield:

: 26218-80-4
6-methoxy-nicotinic acid methyl ester

: 1211515-88-6
2-fluoro-6-methoxypyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: silver(II) fluoride / acetonitrile / 1 h / Inert atmosphere; Glovebox; Sealed tube

2: potassium hydroxide; water / tetrahydrofuran; ethanol

With silver(II) fluoride; water; potassium hydroxide; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/acs.orglett.8b03144

Reference yield:

: 66572-55-2
6-methoxynicotinic acid

: 1211515-88-6
2-fluoro-6-methoxypyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / 3 h

3: silver(II) fluoride / acetonitrile / 1 h / Inert atmosphere; Glovebox; Sealed tube

4: potassium hydroxide; water / tetrahydrofuran; ethanol

With oxalyl dichloride; silver(II) fluoride; water; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/acs.orglett.8b03144