1,4-Piperidinedicarboxylic acid, 4-(2-ethoxy-2-oxoethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester

Base Information

• Chemical Name: 1,4-Piperidinedicarboxylic acid, 4-(2-ethoxy-2-oxoethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester
• CAS No.: 867009-56-1
• Molecular Formula: C17H30NO6
• Molecular Weight: 344.4232
• Hs Code.: 2933399090
• Mol file: 867009-56-1.mol

Synonyms:1,4-Piperidinedicarboxylic acid, 4-(2-ethoxy-2-oxoethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester;4-(2-Ethoxy-2-oxoethyl)-1,4-piperidinedicarboxylicacid1-(1,1-dimethylethyl)4-ethylester;1,4-Piperidinedicarboxylic acid;1-tert-butyl 4-ethyl 4-(2-ethoxy-2-oxoethyl)piperidine-1,4-dicarboxylate

Chemical Property of 1,4-Piperidinedicarboxylic acid, 4-(2-ethoxy-2-oxoethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 404.002°C at 760 mmHg
• PKA: -2.60±0.40(Predicted)
• Flash Point: 198.133°C
• PSA: 82.14000
• Density: 1.103g/cm³
• LogP: 2.45790

Purity/Quality:

98%min ^*data from raw suppliers

1-tert-Butyl 4-ethyl 4-(2-ethoxy-2-oxoethyl)-piperidine-1,4-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Piperidinedicarboxylic acid, 4-(2-ethoxy-2-oxoethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester

There total 1 articles about 1,4-Piperidinedicarboxylic acid, 4-(2-ethoxy-2-oxoethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

ethyl bromoacetate (105-36-2) → C17H29NO6 (867009-56-1)

Guidance literature:

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1.5h;

ethyl bromoacetate; In tetrahydrofuran; at -78 - 20 ℃;

With water; In water;

Reference yield: 14.0%

C17H29NO6 (867009-56-1) + benzylamine (100-46-9) → C20H26N2O4 (867009-58-3)

Guidance literature:

at 160 ℃; for 18h;

Reference yield:

C17H29NO6 (867009-56-1) → 1,1-dimethylethyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylate (236406-38-5)

Guidance literature:

C₁₇H₂₉NO₆; With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; Heating / reflux;

With hydrogenchloride; In ethanol; water; pH=5 - 6;

upstream raw materials:

ethyl bromoacetate

Downstream raw materials:

C₂₀H₂₆N₂O₄

1,1-dimethylethyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylate

Refernces

• 1、 -. "SUBSTITUTED DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS". Page/Page column 38-39. . Retrieved 2008/06/13.