1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-4-(hydroxyMethyl)-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-4-(hydroxyMethyl)-, 1,1-diMethylethyl ester
• CAS No.: 236406-38-5
• Molecular Formula: C₁₃H₂₅NO₄
• Molecular Weight: 259.346
• Hs Code.: 2933399090
• Mol file: 236406-38-5.mol

Synonyms:

Chemical Property of 1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-4-(hydroxyMethyl)-, 1,1-diMethylethyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 378.367oC at 760 mmHg
• PKA: 14.94±0.10(Predicted)
• Flash Point: 182.63oC
• PSA: 70.00000
• Density: 1.095g/cm3
• LogP: 1.31630
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

tert-Butyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)piperidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-4-(hydroxyMethyl)-, 1,1-diMethylethyl ester

There total 11 articles about 1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-4-(hydroxyMethyl)-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1,1-dimethylethyl 1-oxo-2-oxa-8-azaspiro[4,5]decane-8-carboxylate (154348-08-0) → 1,1-dimethylethyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylate (236406-38-5)

Guidance literature:

1,1-dimethylethyl 1-oxo-2-oxa-8-azaspiro[4,5]decane-8-carboxylate; With diisobutylaluminium hydride; In dichloromethane; at -78 - 0 ℃; for 5h;

With water; In dichloromethane; at 0 - 20 ℃;

Reference yield: 54.0%

2-(1-benzyl-4-hydroxymethyl-piperidin-4-yl)-ethanol (40118-06-7) + di-tert-butyl dicarbonate (24424-99-5) → 1,1-dimethylethyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylate (236406-38-5)

Guidance literature:

2-(1-benzyl-4-hydroxymethyl-piperidin-4-yl)-ethanol; With 20% palladium hydroxide-activated charcoal; hydrogen; In 1,4-dioxane; water; acetic acid; for 16h; Inert atmosphere;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; water; at 0 - 20 ℃; for 17h;

Reference yield:

C17H29NO6 (867009-56-1) → 1,1-dimethylethyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylate (236406-38-5)

Guidance literature:

C₁₇H₂₉NO₆; With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; Heating / reflux;

With hydrogenchloride; In ethanol; water; pH=5 - 6;

upstream raw materials:

1,1-dimethylethyl 1-oxo-2-oxa-8-azaspiro[4,5]decane-8-carboxylate

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate

4-ethoxycarbonyl-4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

2-oxa-8-azaspiro[4.5]decane

2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-propionamide

2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-propionamide

2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES". Page/Page column 86; 87. . Retrieved 2008/06/13.
• 2、 -. "Cyclohexane derivatives and their use as therapeutic agents". Page 30. . Retrieved 2010/02/06.