3-Pyridinecarboxylicacid,5-ethenyl-(9CI)

Base Information

• Chemical Name: 3-Pyridinecarboxylicacid,5-ethenyl-(9CI)
• CAS No.: 209915-44-6
• Molecular Formula: C8H7NO2
• Molecular Weight: 149.15
• Mol file: 209915-44-6.mol

Synonyms:3-Pyridinecarboxylicacid,5-ethenyl-(9CI);5-vinylnicotinic acid

Chemical Property of 3-Pyridinecarboxylicacid,5-ethenyl-(9CI)

Chemical Property:

• Melting Point: 154-156 °C
• Boiling Point: 323.6±30.0 °C(Predicted)
• PKA: 2.14±0.10(Predicted)
• PSA: 50.19000
• Density: 1.231±0.06 g/cm3(Predicted)
• LogP: 1.42280

Purity/Quality:

99%min ^*data from raw suppliers

5-ethenyl-3-Pyridinecarboxylicacid 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylicacid,5-ethenyl-(9CI)

There total 2 articles about 3-Pyridinecarboxylicacid,5-ethenyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

5-ethynylnicotinic acid (1211533-87-7) → 5-ethenylnicotinic acid (209915-44-6)

Guidance literature:

With 2,2'-ethane-1,2-diylbissulfanyl-bis-ethanol; hydrogen; In methanol; at 20 ℃; for 24h; under 1551.49 Torr;

DOI:10.1021/jm1007209

Reference yield:

5-bromo-3-pyridinecarboxylic acid (20826-04-4) + tri-n-butyl(vinyl)tin (7486-35-3) → nicotinic acid (59-67-6) + 5-ethenylnicotinic acid (209915-44-6)

Guidance literature:

With lithium hydroxide; caesium carbonate; potassium iodide; Merrifield resin; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; trifuran-2-yl-phosphane; Product distribution; 1.) DMF, 80 deg C, 16h; 2.) DMF, 60 deg C, 48 h; 3.) THF, MeOH, H₂O, reflux, 18 h; different acids, stannanes, catalyst and reaction times;

DOI:10.1016/S0040-4039(98)00778-3

upstream raw materials:

5-bromo-3-pyridinecarboxylic acid

tri-n-butyl(vinyl)tin

5-ethynylnicotinic acid

Refernces

• 1、 Chamoin, Sylvie,Houldsworth, Stephen,Snieckus, Victor. "The stille cross coupling reactions on solid support. Link to solution phase directed ortho metalation. An ester linker approach to styryl, biaryl and heterobiaryl carboxylic acids". . p. 4175 - 4178. Retrieved 2007/10/03.