methyl 3-(4-methoxyphenyl)-3-methylbutanoate

Base Information

• Chemical Name: methyl 3-(4-methoxyphenyl)-3-methylbutanoate
• CAS No.: 67437-37-0
• Molecular Formula: C13H18O3
• Molecular Weight: 222.284
• Hs Code.: 2918999090
• Mol file: 67437-37-0.mol

Synonyms:methyl 3-(4-methoxyphenyl)-3-methylbutanoate

Chemical Property of methyl 3-(4-methoxyphenyl)-3-methylbutanoate

Chemical Property:

• Boiling Point: 110 °C (1.5 mmHg)
• PSA: 35.53000
• LogP: 2.53590

Purity/Quality:

99% ^*data from raw suppliers

Methyl 3-(4-methoxyphenyl)-3-methylbutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-(4-methoxyphenyl)-3-methylbutanoate

There total 5 articles about methyl 3-(4-methoxyphenyl)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-methoxy-phenyl)-3-methyl-butyric acid (1136-01-2) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 3-(4-methoxyphenyl)-3-methylbutanoate (67437-37-0)

Guidance literature:

3-(4-methoxy-phenyl)-3-methyl-butyric acid; diazomethyl-trimethyl-silane; In methanol; toluene; for 0.75h;

With acetic acid; In toluene;

Reference yield:

Methyl-2-cyano-3-(p-methoxyphenyl)-3-methylbutanoat (1149-92-4) → methyl 3-(4-methoxyphenyl)-3-methylbutanoate (67437-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethane-1,2-diol / Heating

2: (i) SOCl₂, (ii) /BRN= 1098229/

With potassium hydroxide; In ethylene glycol;

DOI:10.1021/ja00481a025

Reference yield:

3-Methylbutenoic acid (541-47-9) → methyl 3-(4-methoxyphenyl)-3-methylbutanoate (67437-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / 2 h / 65 °C

2: methanol; toluene / 0.75 h

With aluminum (III) chloride; In methanol; dichloromethane; toluene;

upstream raw materials:

methanol

3-(4-methoxy-phenyl)-3-methyl-butyric acid

Methyl-2-cyano-3-(p-methoxyphenyl)-3-methylbutanoat

diazomethyl-trimethyl-silane

Downstream raw materials:

1,1-Diphenyl-2-(p-methoxyphenyl)-3,3-dimethylcyclopropan

1,1-Diphenyl-3-(p-methoxyphenyl)-3-methyl-1-buten

methyl 3-(3-iodo-4-methoxyphenyl)-3-methylbutanoate

methyl 3-[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-methylbutanoate

Refernces