3-(4-methoxyphenyl)-3-methylbutanoic acid

Base Information

• Chemical Name: 3-(4-methoxyphenyl)-3-methylbutanoic acid
• CAS No.: 1136-01-2
• Molecular Formula: C12H16 O3
• Molecular Weight: 208.257
• Mol file: 1136-01-2.mol

Synonyms:Hydrocinnamicacid, p-methoxy-b,b-dimethyl- (6CI,8CI); NSC 245189

Chemical Property of 3-(4-methoxyphenyl)-3-methylbutanoic acid

Chemical Property:

• Vapor Pressure: 5.64E-05mmHg at 25°C
• Boiling Point: 332.9°C at 760 mmHg
• Flash Point: 124.4°C
• Density: 1.088g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-methoxyphenyl)-3-methylbutanoic acid

There total 12 articles about 3-(4-methoxyphenyl)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

3-Methylbutenoic acid (541-47-9) + methoxybenzene (100-66-3) → 3-(4-methoxy-phenyl)-3-methyl-butyric acid (1136-01-2)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 40 ℃;

DOI:10.1021/acs.jmedchem.1c00947

Reference yield: 32.0%

β-bromo-isovaleric acid (5798-88-9) + methoxybenzene (100-66-3) → 3-(4-methoxy-phenyl)-3-methyl-butyric acid (1136-01-2)

Guidance literature:

β-bromo-isovaleric acid; methoxybenzene; aluminum (III) chloride; at 20 - 35 ℃; for 4h;

With water; at 0 ℃; for 1.33333h;

With hydrogen bromide; In water;

Reference yield:

Methyl-2-cyano-3-(p-methoxyphenyl)-3-methylbutanoat (1149-92-4) → 3-(4-methoxy-phenyl)-3-methyl-butyric acid (1136-01-2)

Guidance literature:

With potassium hydroxide; In ethylene glycol; Heating;

DOI:10.1021/ja00481a025

upstream raw materials:

3-(4-methoxy-phenyl)-3-methyl-butyric acid ethyl ester

methoxybenzene

3-Chloro-2-methylpropene

methyl 3-(4-hydroxyphenyl)-3-methylbutanoate

Downstream raw materials:

6-methoxy-3,3-dimethylindan-1-one

3-p-Anisyl-3-methyl-1-butanol

β-<4-Methoxy-phenyl>-isovaleriansaeure-chlorid

methyl 3-(4-methoxyphenyl)-3-methylbutanoate