Benzeneacetamide, -alpha-,4-dimethyl-

Base Information

• Chemical Name: Benzeneacetamide, -alpha-,4-dimethyl-
• CAS No.: 127462-35-5
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• Mol file: 127462-35-5.mol

Synonyms:Benzeneacetamide, -alpha-,4-dimethyl-;2-p-tolylpropanaMide

Chemical Property of Benzeneacetamide, -alpha-,4-dimethyl-

Chemical Property:

• PSA: 43.09000
• LogP: 2.28410

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetamide, -alpha-,4-dimethyl-

There total 6 articles about Benzeneacetamide, -alpha-,4-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + carbon monoxide (201230-82-2) → (+/-)-2-(4'-methylphenyl)-propylamide (127462-35-5)

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; ammonium chloride; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 15h; under 22801.5 Torr; regioselective reaction;

DOI:10.1039/c7sc04054g

Reference yield: 42.0%

2-bromo-N-cyclopropyl-N-tosylpropanamide → (+/-)-2-(4'-methylphenyl)-propylamide (127462-35-5)

Guidance literature:

With manganese; bis[2-(diphenylphosphino)phenyl] ether; cobalt(II) chloride; In tetrahydrofuran; at 100 ℃; for 48h; chemoselective reaction; Sealed tube;

DOI:10.1002/chem.202005129

Reference yield: 11.0%

2-(4-tolyl)-2-(trimethylsiloxy)propanenitrile (69813-79-2) → (+/-)-2-(4'-methylphenyl)-propionitrile (75920-45-5) + (+/-)-2-(4'-methylphenyl)-propylamide (127462-35-5) + para-methylacetophenone (122-00-9)

Guidance literature:

With chloro-trimethyl-silane; water; acetonitrile; sodium iodide; In hexane; for 24h; Ambient temperature;

DOI:10.1246/bcsj.62.3537

upstream raw materials:

(+/-)-2-(4'-methylphenyl)-propionitrile

2-(4-tolyl)-2-(trimethylsiloxy)propanenitrile

2,4-dimethylacetophenone.

1-ethenyl-4-methylbenzene