75920-45-5

Basic information

• Product Name: (+/-)-2-(4'-methylphenyl)-propionitrile
• Synonyms: (+/-)-2-(4'-methylphenyl)-propionitrile
• CAS NO: 75920-45-5
• Molecular Weight: 145.204
• Mol File: 75920-45-5.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: (+/-)-2-(4'-methylphenyl)-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-2-(4'-methylphenyl)-propionitrile(75920-45-5)
• EPA Substance Registry System: (+/-)-2-(4'-methylphenyl)-propionitrile(75920-45-5)

Safety Data

• Hazardous Substances Data: 75920-45-5(Hazardous Substances Data)

Upstream product

• 2947-61-7 (4-methylphenyl)acetonitrile 
• 74-88-4 methyl iodide 
• 122-00-9 para-methylacetophenone 
• 7677-24-9 trimethylsilyl cyanide 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 
• 124-38-9 carbon dioxide 
• 77287-34-4 formamide 
• 766-97-2 4-n-methylphenylacetylene 
• 557-21-1 zinc(II) cyanide 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 773837-37-9 sodium cyanide 
• 2362-36-9 1-(1-chloroethyl)-4-methylbenzene 
• 67-56-1 methanol 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 938-94-3 (R,S)-2-(4'-methylphenyl) propionic acid 
• 127462-35-5 (+/-)-2-(4'-methylphenyl)-propylamide 
• 151061-74-4 (R)-(-)-2-(4'-methylphenyl)propionamide 
• 124709-72-4 (S)-(+)-2-(4'-methylphenyl)propanoic acid 
• 171779-51-4 2-Methyl-2-(4-methylphenyl)-5-bromo-5-hexen-1-al 
• 111128-12-2 2-[4-(bromomethyl)phenyl]propanoic acid 
• 1372209-58-9 N-methyl-2-(p-tolyl)propanamide 

Relevant articles and documents

A convenient reductive removal of benzylic hydroxyl and trimethylsilyloxyl groups with Me3SiCl-NaI-MeCN reagent

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Rhenium(I)-Catalyzed C-Methylation of Ketones, Indoles, and Arylacetonitriles Using Methanol

A ReCl(CO)5/MeC(CH2PPh2)3 (L2) system was developed for the C-methylation reactions utilizing methanol and base, following the borrowing hydrogen strategy. Diverse ketones, indoles, and arylacetonitriles underwent mono-and dimethylation selectively up to 99% yield. Remarkably, tandem multiple methylations were also achieved by employing this catalytic system.

Time Programmable Locking/Unlocking of the Calix[4]arene Scaffold by Means of Chemical Fuels

In this work, we report that 2-cyano-2-phenylpropanoic acid and its p-Cl, p-CH3 and p-OCH3 derivatives can be used as chemical fuels to control the geometry of the calix[4]arene scaffold in its cone conformation. It is shown that, under the action of the fuel, the cone calix[4]arene platform assumes a “locked” shape with two opposite aromatic rings strongly convergent and the other two strongly divergent (“pinched cone” conformation). Only when the fuel is exhausted, the cone calix[4]arene scaffold returns to its resting, “unlocked” shape. Remarkably, the duration of the “locked” state can be controlled at will by varying the fuel structure or amount. A kinetic study of the process shows that the consume of the fuel is catalyzed by the “unlocked” calixarene that behaves as an autocatalyst for its own production. A mechanism is proposed for the reaction of fuel consumption.