1-(T-BUTYLOXYCARBONYL)-2-TRIPHENYLPHOSPHONIUMHYDRAZINE BROMIDE

Base Information

• Chemical Name: 1-(T-BUTYLOXYCARBONYL)-2-TRIPHENYLPHOSPHONIUMHYDRAZINE BROMIDE
• CAS No.: 356534-53-7
• Molecular Formula: Br*C₂₃H₂₆N₂O₂P
• Molecular Weight: 473.349
• Mol file: 356534-53-7.mol

Synonyms:BOC-HNNH-PPH3 BR;1-BOC-2-TRIPHENYLPHOSPHONIUM-HYDRAZINE BROMIDE;1-(T-BUTYLOXYCARBONYL)-2-TRIPHENYLPHOSPHONIUMHYDRAZINE BROMIDE;1-(TERT-BUTYLOXYCARBONYL)-2-TRIPHENYLPHOSPHONIUM-HYDRAZINE BROMIDE

Chemical Property of 1-(T-BUTYLOXYCARBONYL)-2-TRIPHENYLPHOSPHONIUMHYDRAZINE BROMIDE

Chemical Property:

• PSA: 63.95000
• LogP: 1.71060

Purity/Quality:

98%min ^*data from raw suppliers

1-(T-Butyloxycarbonyl)-2-triphenylphosphoniumhydrazinebromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(T-BUTYLOXYCARBONYL)-2-TRIPHENYLPHOSPHONIUMHYDRAZINE BROMIDE

There total 3 articles about 1-(T-BUTYLOXYCARBONYL)-2-TRIPHENYLPHOSPHONIUMHYDRAZINE BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

t-butoxycarbonylhydrazine (870-46-2) + dibromotriphenylphosphorane (1034-39-5) → t-butyl carbazate triphenylphosphine bromide (356534-53-7)

Guidance literature:

With triethylamine; In toluene; at 20 ℃; for 6h;

DOI:10.1021/ol0160856

Reference yield: 64.0%

t-butoxycarbonylhydrazine (870-46-2) + bromotriphenylphosphonium bromide (5758-24-7) → t-butyl carbazate triphenylphosphine bromide (356534-53-7)

Guidance literature:

In toluene; for 6h;

DOI:10.1021/ja039643f

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → t-butyl carbazate triphenylphosphine bromide (356534-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 78.1 percent / hydrazine monohydrate / propan-2-ol / 0.33 h / 20 °C

2: 64 percent / toluene / 6 h

With hydrazine hydrate; In isopropyl alcohol; toluene;

DOI:10.1021/ja039643f

upstream raw materials:

t-butoxycarbonylhydrazine

dibromotriphenylphosphorane

bromotriphenylphosphonium bromide

di-tert-butyl dicarbonate

Downstream raw materials:

N^α-acetyl-N^β-(tert-butyloxycarbonyl)-N^α-methylhydrazine

Refernces

• 1、 Tsubrik, Olga,Maeeorg, Uno. "Combination of tert-butoxycarbonyl and triphenylphosphonium protecting groups in the synthesis of substituted hydrazines". . p. 2297 - 2299. Retrieved 2007/10/03.