1034-39-5Relevant articles and documents
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Smissman et al.
, p. 1640 (1975)
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Burton,D.J.,Wiemers,D.M.
, p. 85 (1985)
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Peach
, p. 565 (1977)
Chemistry of iminofurans: X. Synthesis and hydrolysis of 5-aryl(hetaryl)-2-[(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)imino]furan-3(2H)-ones
Panchenko,Shipilovskikh,Rubtsov
, p. 343 - 348 (2016)
5-Aryl(hetaryl)furan-2,3-diones reacted with N-(triphenyl-λ5-phosphanylidene)-4,5,6,7-tetrahydro-1-benzothiophen-2-amines to give 5-aryl(hetaryl)-2-[(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)imino]furan-3(2H)-ones whose acid hydrolysis afforded 4-aryl(hetaryl)-2-hydroxy-4-oxo-N-(4,5,6,7-tetrahydro-1-benzothiophen- 2-yl)but-2-enamides.
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Pande,K.C.,Trampe,G.
, p. 1169 - 1171 (1970)
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Synthesis and 17O NMR spectroscopy of a series of 17O labeled triarylphosphine oxides
Pomerantz, Martin,Terrazas, Michael S.,Cheng, Yang,Gu, Xiaomin
, p. 505 - 508 (1996)
A series of nine 17O labeled triarylphosphine oxides [(p-R-C6H4)3PO] was synthesized, 17O NMR spectroscopic studies were carried out (toluene solvent/95 °C and CDCl3/60 °C) and the spectrum was fit with two Lorentzian peaks. The chemical shifts range from δ 51.8 to 55.7 in toluene and δ 44.8 to 48.9 in CDCl3, while 1JPO varies from 159.6 to 168.6 Hz in toluene. The data were fit to the Taft DSP and Hammett equations and related to other NMR parameters for this system and the analogous λ5-phosphazenes [(p-R-C6H4)3PNPh]. Using the Taft DSP equation the 17O substituent chemical shifts gave ρI and ρR with opposite signs which is different from what is observed with the λ5-phosphazenes. 1JPO, on the other hand correlates best with the Hammett σ+p constants. The data are consistent with a triple bond contribution to the PO bonding.
CRYSTALLINE FORMS OF 4-(1-(1,1-DI(PYRIDIN-2-YL)ETHYL)-6-(3,5-DIMETHYLISOXAZOL-4-YL)-1H- PYRROLO[3,2-B]PYRIDIN-3-YL)BENZOIC ACID THAT INHIBITS BROMODOMAIN
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Paragraph 0135, (2018/10/19)
Forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-3-yl)benzoic acid were prepared and characterized in the solid state: Compound I. Also provided are processes of manufacture and methods of using the forms of Compound I.
Structure-property relationships in a series of diglycerol tetraether model lipids and their lyotropic assemblies: The effect of branching topology and chirality
Markowski, Thomas,Drescher, Simon,Meister, Annette,Blume, Alfred,Dobner, Bodo
, p. 3649 - 3662 (2014/06/09)
Three novel diglycerol tetraether lipids with one membrane-spanning chain have been synthesized. These lipids contain only two or four racemic methyl branches at selected positions of the hydrophobic chains in contrast to natural lipids from archaebacterial membranes with an isoprenoid substitution pattern. The insertion of the methyl moieties was realized starting from either (RS)-citronellyl bromide or the inexpensive methyl malonic acid ethyl ester. For chain elongation the Cu-catalysed Grignard coupling reaction was used. The preparation of diglycerol tetraethers was either performed by condensing suitable blocked monoglycerol diethers by Grubbs metathesis or by reaction of the transmembrane C32-chain with blocked glycerols followed by further alkylation steps. Finally, we could show that the resulting lipids can form closed lipid vesicles comparable to the optically pure counterparts. Therefore, these much simpler lipids compared to the natural lipids from archaebacterial membranes are also suitable for preparation of stable tailored liposomes. This journal is the Partner Organisations 2014.
