Technology Process of 4-BroMo-2-forMylthiophene-3-carboxylic acid
There total 1 articles about 4-BroMo-2-forMylthiophene-3-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-bromo-3-thiophenecarboxylic acid;
With
lithium diisopropyl amide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;
at -78 ℃;
for 1h;
N,N-dimethyl-formamide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;
at -78 - 20 ℃;
for 0.75h;
- Guidance literature:
-
4-bromo-2-formyl-thiophene-3-carboxylic acid;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.166667h;
ethyl iodide;
at 50 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
1.2: 3 h / 50 °C
2.1: hydrazine hydrate / ethanol / 5 h / Reflux; Inert atmosphere
3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 45 °C / Inert atmosphere; Cooling with ice
4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 0.5 h / 110 °C / Microwave irradiation
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;