2-(2-Fluoroethoxy)ethanol

Base Information

• Chemical Name: 2-(2-Fluoroethoxy)ethanol
• CAS No.: 373-22-8
• Molecular Formula: C4H9FO2
• Molecular Weight: 108.113
• Hs Code.: 2909499000
• European Community (EC) Number: 839-422-2
• DSSTox Substance ID: DTXSID50190748
• Nikkaji Number: J34.785J
• Wikidata: Q83063148
• Mol file: 373-22-8.mol

Synonyms:2-(2-fluoroethoxy)ethanol;373-22-8;ETHANOL, 2-(beta-FLUOROETHOXY)-;2-(2-fluoroethoxy)ethan-1-ol;Ethanol, 2-(2-fluoroethoxy)-;2-(beta-Fluoroethoxy)ethanol;2-Fluoro-2'-hydroxydiethyl ether;BRN 1733453;C4H9FO2;AI3-50937;4-01-00-02378 (Beilstein Handbook Reference);SCHEMBL92157;DTXSID50190748;AIQHGORLUMRDSE-UHFFFAOYSA-N;C4-H9-F-O2;MFCD01727880;AKOS022504363;AT25497;LS-66793;NS-01006;CS-0199113;EN300-4293768;A901226

Chemical Property of 2-(2-Fluoroethoxy)ethanol

Chemical Property:

• Vapor Pressure: 0.867mmHg at 25°C
• Boiling Point: 159.7°Cat760mmHg
• Flash Point: 82.4°C
• PSA: 29.46000
• Density: 1.04g/cm³
• LogP: -0.03520
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 108.05865769
• Heavy Atom Count: 7
• Complexity: 32.9

Purity/Quality:

99%, ^*data from raw suppliers

2-(2-Fluoroethoxy)ethanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COCCF)O

Technology Process of 2-(2-Fluoroethoxy)ethanol

There total 8 articles about 2-(2-Fluoroethoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.01%

(2-fluoroethoxy)acetic acid benzyl ester → 2-(2-fluoroethoxy)ethanol (373-22-8)

Guidance literature:

With lithium aluminium tetrahydride; at 0 - 20 ℃; for 3h;

Reference yield:

[1,3]-dioxolan-2-one (96-49-1) + 2-fluoroethanol (371-62-0) → 2-(2-fluoroethoxy)ethanol (373-22-8)

Guidance literature:

2-fluoroethanol; With tetrabutylammomium bromide; triethylamine; at 20 ℃; for 0.0833333h;

[1,3]-dioxolan-2-one; at 100 ℃; for 18h;

Reference yield:

oxirane (75-21-8,99932-75-9) → 2-(2-fluoroethoxy)ethanol (373-22-8)

Guidance literature:

With diethyl ether; hydrogen fluoride; at 100 ℃;

upstream raw materials:

oxirane

2-fluoroethanol

[1,3]-dioxolan-2-one

((2-(2-fluoroethoxy)ethoxy)methyl)benzene

Downstream raw materials:

1,13-difluoro-3,6,8,11-tetraoxa-tridecane

2-(2-fluoroethoxy)ethyl 4-methylbenzenesulfonate

Refernces

• 1、 Van Oosten, Erik M.,Wilson, Alan A.,Mamo, David C.,Pollock, Bruce G.,Mulsant, Benoit H.,Houle, Sylvain,Vasdev, Neil. "Towards the development of new subtype-specific muscarinic receptor radiopharmaceuticals - Radiosynthesis and ex vivo biodistribution of [ 18F]3-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethylthio)-1,2, 5-thiadiazol-3-yl)-1-methyl-1,2,5,6-tetrahydropyrid". experimental part. p. 1222 - 1232. Retrieved 2011/02/24.