2-Piperazinecarboxylicacid,3-carbamoyl-(6CI)

Base Information

• Chemical Name: 2-Piperazinecarboxylicacid,3-carbamoyl-(6CI)
• CAS No.: 98549-53-2
• Molecular Formula: C6 H11 N3 O3
• Molecular Weight: 0
• Mol file: 98549-53-2.mol

Synonyms:2-Piperazinecarboxylicacid,3-carbamoyl-(6CI);3-CARBAMOYLPIPERAZINE-2-CARBOXYLIC ACID

Chemical Property of 2-Piperazinecarboxylicacid,3-carbamoyl-(6CI)

Chemical Property:

• Melting Point: 189 - 190 °C
• PSA: 104.45000
• LogP: -1.15580

Purity/Quality:

99%min ^*data from raw suppliers

3-(aminocarbonyl)-2-Piperazinecarboxylicacid 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Piperazinecarboxylicacid,3-carbamoyl-(6CI)

There total 2 articles about 2-Piperazinecarboxylicacid,3-carbamoyl-(6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrazine-2,3-dicarboxamide (6164-78-9) → cis-3-(aminocarbonyl)-2-piperazinecarboxylic acid (79744-11-9,98549-53-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In water; for 20h; under 2585.7 Torr; Ambient temperature;

DOI:10.1021/jm00143a013

Reference yield:

→ 3-carbamoyl-piperazine-2-carboxylic acid (98549-53-2)

Guidance literature:

Pyrazin-2,3-dicarbonsaeure-monoamid, Hydrierung an Pd in wss. KOH (50grad);

DOI:10.1093/japr/10.1.24

Reference yield: 53.0%

cis-3-(aminocarbonyl)-2-piperazinecarboxylic acid (79744-11-9,98549-53-2) + ethyl bromoacetate (105-36-2) → diethyl cis-2-(aminocarbonyl)-3-<(2-ethoxy-2-oxoethoxy)carbonyl>-1,4-piperazinediacetate (79744-12-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 60 ℃; for 3.5h;

DOI:10.1021/jm00143a013

upstream raw materials:

pyrazine-2,3-dicarboxamide

Downstream raw materials:

diethyl cis-2-(aminocarbonyl)-3-<(2-ethoxy-2-oxoethoxy)carbonyl>-1,4-piperazinediacetate

diphenyl(2-piperazine-3-carboxyamide-carboxy)borane

Refernces