4-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-

Base Information

• Chemical Name: 4-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-
• CAS No.: 36705-82-5
• Molecular Formula: C10H7NO3S
• Molecular Weight: 221.236
• Mol file: 36705-82-5.mol

Synonyms:4-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-;2-(4-Hydroxy-phenyl)-thiazole-4-carboxylic acid;2-(4-hydroxyphenyl)-4-thiazolecarboxylic acid

Chemical Property of 4-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-

Chemical Property:

• Melting Point: 218-221 °C
• Boiling Point: 493.0±51.0 °C(Predicted)
• PKA: 8.89±0.15(Predicted)
• PSA: 98.66000
• Density: 1.490±0.06 g/cm3(Predicted)
• LogP: 2.21390

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Hydroxy-phenyl)-thiazole-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-

There total 4 articles about 4-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxythiobenzamide (25984-63-8) + bromopyruvic acid (1113-59-3) → 2-(4-Hydroxyphenyl)-1,3-thiazole-4-carboxylic acid (36705-82-5)

Guidance literature:

With hydrogenchloride; potassium hydroxide; In methanol; water;

Reference yield:

4-cyanophenol (767-00-0) → 2-(4-Hydroxyphenyl)-1,3-thiazole-4-carboxylic acid (36705-82-5)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂S, Et₃N / pyridine

3: aq. NaOH / Heating

With sodium hydroxide; hydrogen sulfide; triethylamine; In pyridine;

DOI:10.1021/ja00764a044

Reference yield:

2-(4-hydroxy-phenyl)-thiazole-4-carboxylic acid methyl ester (36727-07-8) → 2-(4-Hydroxyphenyl)-1,3-thiazole-4-carboxylic acid (36705-82-5)

Guidance literature:

With sodium hydroxide; Heating;

DOI:10.1021/ja00764a044

upstream raw materials:

2-(4-hydroxy-phenyl)-thiazole-4-carboxylic acid methyl ester

4-hydroxythiobenzamide

4-cyanophenol

bromopyruvic acid

Downstream raw materials:

2-(4-Hydroxyphenyl)-1,3-thiazole-4-carboxamide

2-{4-[(2-chloroethyl)oxy]phenyl}-1,3-thiazole-4-carboxamide