1-(4-Methoxybenzyl)piperidin-3-ol

Base Information

• Chemical Name: 1-(4-Methoxybenzyl)piperidin-3-ol
• CAS No.: 148729-36-6
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.299
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID301273148
• Mol file: 148729-36-6.mol

Synonyms:1-(4-methoxybenzyl)piperidin-3-ol;148729-36-6;1-(4-Methoxy-benzyl)-piperidin-3-ol;1-[(4-methoxyphenyl)methyl]piperidin-3-ol;3-Piperidinol, 1-[(4-methoxyphenyl)methyl]-;Oprea1_331102;DTXSID301273148;AKOS009098105;1-[(4-Methoxyphenyl)methyl]-3-piperidinol;A884333;SR-01000201540;SR-01000201540-1

Chemical Property of 1-(4-Methoxybenzyl)piperidin-3-ol

Chemical Property:

• PSA: 32.70000
• LogP: 1.58980
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 221.141578849
• Heavy Atom Count: 16
• Complexity: 202

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Methoxybenzyl)piperidin-3-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CN2CCCC(C2)O

Technology Process of 1-(4-Methoxybenzyl)piperidin-3-ol

There total 2 articles about 1-(4-Methoxybenzyl)piperidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

3-hydroxypiperazine (6859-99-0) + 4-methoxy-benzaldehyde (123-11-5) → 1-(4-Methoxy-benzyl)-piperidin-3-ol (148729-36-6)

Guidance literature:

With borane pyridine; In ethanol;

DOI:10.1080/00397919308009840

Reference yield:

3-hydroxypiperazine (6859-99-0) + p-methoxybenzyl chloride (824-94-2) → 1-(4-Methoxy-benzyl)-piperidin-3-ol (148729-36-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃;

DOI:10.1016/j.bmc.2006.09.052

Reference yield:

1-(4-Methoxy-benzyl)-piperidin-3-ol (148729-36-6) → C13H17NO2

Guidance literature:

With trimethyl-sulfo-ammonium betaine; dimethyl sulfoxide; triethylamine; at 20 ℃;

DOI:10.1016/j.bmc.2006.09.052

upstream raw materials:

3-hydroxypiperazine

4-methoxy-benzaldehyde

p-methoxybenzyl chloride