(S)-2,4,6-TRIMETHYLBENZENESULFINAMIDE

Base Information

• Chemical Name: (S)-2,4,6-TRIMETHYLBENZENESULFINAMIDE
• CAS No.: 607729-50-0
• Molecular Formula: C9H13NOS
• Molecular Weight: 183.274
• Hs Code.: 2930909899
• Mol file: 607729-50-0.mol

Synonyms:(S)-2,4,6-TRIMETHYLBENZENESULFINAMIDE

Chemical Property of (S)-2,4,6-TRIMETHYLBENZENESULFINAMIDE

Chemical Property:

• Melting Point: 120-122 °C
• Boiling Point: 350.1±52.0 °C(Predicted)
• PKA: 9.55±0.50(Predicted)
• PSA: 62.30000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: 3.15910
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

(S)-2,4,6-Trimethylbenzenesulfinamide 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2,4,6-TRIMETHYLBENZENESULFINAMIDE

There total 10 articles about (S)-2,4,6-TRIMETHYLBENZENESULFINAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,4,6-Trimethyl-benzenesulfinic acid (1R,2S)-1-phenyl-2-(toluene-4-sulfonylamino)-propyl ester → N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-4-methylbenzene sulfonamide (108591-33-9) + (S)-(+)-2,4,6-trimethylbenzenesulfinamide (607729-50-0)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 - -45 ℃;

DOI:10.1016/j.tet.2005.03.122

Reference yield: 70.0%

(SS,1S,2R)-(-)-2,4,6-trimethylbenzenesulfinic acid 1-(2,4,6-trimethylbenzenesulfonylamino)-2-indan-2-yl ester → (S)-(+)-2,4,6-trimethylbenzenesulfinamide (607729-50-0)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/jo030142m

Reference yield: 45.0%

2,4,6-Trimethyl-benzenesulfinic acid (1S,2R)-1-amino-indan-2-yl ester → (Rs)-2,4,6-trimethylbenzenesulfinamide (446021-73-4) + (S)-(+)-2,4,6-trimethylbenzenesulfinamide (607729-50-0)

Guidance literature:

With ammonia; lithium; ferric nitrate; In tetrahydrofuran; cooling;

DOI:10.1021/jo035675+

upstream raw materials:

(S)-N-chloroacetyl-2,4,6-trimethylbenzenesulfinamide

2,4,6-trimethylbenzenesulphinamide

N-chloroacetyl-2,4,6-trimethylbenzenesulfinamide

2-mesitylmagnesium bromide

Downstream raw materials:

(S)-(+)-N-(benzylidene)-2,4,6-trimethylbenzenesulfinamide

(S)-N-2,4,6-trimethylbenzenesulfinyl benzaldehyde imine

Refernces

• 1、 Roe, Caroline,Hobbs, Heather,Stockman, Robert A.. "One-pot synthesis of chiral nonracemic amines". experimental part. p. 9452 - 9459. Retrieved 2012/01/06.
• 2、 Savile, Christopher K.,Magloire, Vladimir P.,Kazlauskas, Romas J.. "Subtilisin-catalyzed resolution of N-acyl arylsulfinamides". . p. 2104 - 2113. Retrieved 2007/10/03.