2-[4-(2-Aminoethyl)piperazin-1-yl]ethanol

Base Information

• Chemical Name: 2-[4-(2-Aminoethyl)piperazin-1-yl]ethanol
• CAS No.: 20542-08-9
• Molecular Formula: C8 H19 N3 O
• Molecular Weight: 173.258
• DSSTox Substance ID: DTXSID00406306
• Wikidata: Q82211215
• Mol file: 20542-08-9.mol

Synonyms:20542-08-9;2-[4-(2-aminoethyl)piperazin-1-yl]ethanol;2-[4-(2-Amino-ethyl)-piperazin-1-yl]-ethanol;2-(4-(2-aminoethyl)piperazin-1-yl)ethanol;MFCD06446849;2-[4-(2-aminoethyl)piperazin-1-yl]ethan-1-ol;2-(4-(2-Aminoethyl)piperazin-1-yl)ethan-1-ol;1-Piperazineethanol, 4-(2-aminoethyl)-;C8H19N3O;SCHEMBL1306795;DTXSID00406306;YISZZNVEUSLMJR-UHFFFAOYSA-N;4-(aminoethyl)piperazine-1-ethanol;4-(aminoethyl) piperazine-1-ethanol;AKOS002664727;N-aminoethyl-N'-hydroxyethylpiperazine;CS-0358634;2-[4-(2-Amino-ethyl)-piperazin-1-yl]ethanol;E89175;EN300-7793724

Chemical Property of 2-[4-(2-Aminoethyl)piperazin-1-yl]ethanol

Chemical Property:

• PSA: 52.73000
• LogP: -0.86890
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 173.152812238
• Heavy Atom Count: 12
• Complexity: 113

Purity/Quality:

95% ^*data from raw suppliers

2-[4-(2-Amino-ethyl)-piperazin-1-yl]-ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CCN)CCO
• Uses: 2-[4-(2-Amino-ethyl)-piperazin-1-yl]-ethanol is used in preparation of tetrahydro-imidazoquinoline carboxylates as CBP/p300 inhibitors and therapeutic uses thereof.

Technology Process of 2-[4-(2-Aminoethyl)piperazin-1-yl]ethanol

There total 3 articles about 2-[4-(2-Aminoethyl)piperazin-1-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-(4-(2-hydroxyethyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione (6820-92-4) → 2-(4-(2-aminoethyl)piperazin-1-yl)ethan-1-ol (20542-08-9)

Guidance literature:

2-(2-(4-(2-hydroxyethyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione; With hydrazine hydrate;

With hydrogenchloride;

With sodium hydroxide;

DOI:10.1002/jccs.201300321

Reference yield:

1-(2-hydroxyethyl)piperazine (103-76-4) → 2-(4-(2-aminoethyl)piperazin-1-yl)ethan-1-ol (20542-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 10 h / 80 - 85 °C

2: hydrazine hydrate

With potassium carbonate; hydrazine hydrate; In acetonitrile;

DOI:10.1002/jccs.201300321

Reference yield:

→ 2-(4-(2-aminoethyl)piperazin-1-yl)ethan-1-ol (20542-08-9)

Guidance literature:

1-Cyanurethyl-2-(2-hydroxy-aethyl)-piperazin, H2, A., Raney-Ni;

upstream raw materials:

1-(2-hydroxyethyl)piperazine

2-(2-(4-(2-hydroxyethyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione