N-Benzyl-2-phenoxynicotinamide

Base Information

• Chemical Name: N-Benzyl-2-phenoxynicotinamide
• CAS No.: 125038-44-0
• Molecular Formula: C₁₉H₁₆N₂O₂
• Molecular Weight: 304.348
• Mol file: 125038-44-0.mol

Synonyms:N-Benzyl-2-phenoxynicotinamide

Chemical Property of N-Benzyl-2-phenoxynicotinamide

Chemical Property:

• PSA: 51.22000
• LogP: 4.19480

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzyl-2-phenoxynicotinamide

There total 4 articles about N-Benzyl-2-phenoxynicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloronicotinamide + phenol (108-95-2,27073-41-2) → N-Benzyl-2-Phenoxy nicotinamide (125038-44-0)

Guidance literature:

In water; N,N-dimethyl-formamide;

Reference yield:

2-chloronicotinic acid (2942-59-8) → N-Benzyl-2-Phenoxy nicotinamide (125038-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -10 deg C, 30 min, 2.) RT, 18 h

2: 1.) NaH / 1.) DMF, 20 min, 2.) reflux, 1 h

With 4-methyl-morpholine; sodium hydride; isobutyl chloroformate;

DOI:10.1021/jm00105a015

Reference yield:

benzylamine (100-46-9) → N-Benzyl-2-Phenoxy nicotinamide (125038-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -10 deg C, 30 min, 2.) RT, 18 h

2: 1.) NaH / 1.) DMF, 20 min, 2.) reflux, 1 h

With 4-methyl-morpholine; sodium hydride; isobutyl chloroformate;

DOI:10.1021/jm00105a015

upstream raw materials:

2-chloronicotinic acid benzylamine

phenol

2-chloronicotinic acid

benzylamine