1-Azaspiro[4.7]dodecane

Base Information

• Chemical Name: 1-Azaspiro[4.7]dodecane
• CAS No.: 127687-61-0
• Molecular Formula: C₁₁H₂₁N
• Molecular Weight: 167.294
• Mol file: 127687-61-0.mol

Synonyms:1-Azaspiro[4.7]dodecane

Chemical Property of 1-Azaspiro[4.7]dodecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Azaspiro[4.7]dodecane

There total 4 articles about 1-Azaspiro[4.7]dodecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-benzylspiro[pyrrolidine-2,1'-cyclooctane] (216369-62-9) → spiro[pyrrolidine-2,1'-cyclooctane] (127687-61-0)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 5h; Heating;

Reference yield:

cycloactanone (502-49-8) → spiro[pyrrolidine-2,1'-cyclooctane] (127687-61-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: benzene / Heating

2.1: 65 percent / diethyl ether / 4 h / 30 - 35 °C

3.1: Hg(OAc)2 / tetrahydrofuran; H₂O / 10 h / 20 °C

3.2: 62 percent / NaBH₄ / aq. NaOH / 0 °C

4.1: 88 percent / ammonium formate / 10 percent Pd/C / methanol / 5 h / Heating

With mercury(II) diacetate; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; water; benzene; 1.1: Condensation / 2.1: Grignard reaction / 3.1: aminomercuration / 3.2: Cyclization / 4.1: Hydrogenolysis;

Reference yield:

N-cyclooctylidene(phenyl)methanamine (15922-50-6) → spiro[pyrrolidine-2,1'-cyclooctane] (127687-61-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 65 percent / diethyl ether / 4 h / 30 - 35 °C

2.1: Hg(OAc)2 / tetrahydrofuran; H₂O / 10 h / 20 °C

2.2: 62 percent / NaBH₄ / aq. NaOH / 0 °C

3.1: 88 percent / ammonium formate / 10 percent Pd/C / methanol / 5 h / Heating

With mercury(II) diacetate; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; water; 1.1: Grignard reaction / 2.1: aminomercuration / 2.2: Cyclization / 3.1: Hydrogenolysis;

upstream raw materials:

1-benzylspiro[pyrrolidine-2,1'-cyclooctane]

cycloactanone

N-cyclooctylidene(phenyl)methanamine

N-(1-allylcyclooctyl)benzylamine

Refernces