4-bromo-2-methoxy-6-methylbenzoic acid

Base Information

• Chemical Name: 4-bromo-2-methoxy-6-methylbenzoic acid
• CAS No.: 877149-08-1
• Molecular Formula: C9H9BrO3
• Molecular Weight: 245.073
• Hs Code.: 2918990090
• Mol file: 877149-08-1.mol

Synonyms:4-bromo-2-methoxy-6-methylbenzoic acid;Benzoic acid, 4-broMo-2-Methoxy-6-Methyl-

Chemical Property of 4-bromo-2-methoxy-6-methylbenzoic acid

Chemical Property:

• PSA: 46.53000
• LogP: 2.46430
• Storage Temp.: 2-8°C

Purity/Quality:

90-99.99% ^*data from raw suppliers

4-Bromo-2-methoxy-6-methylbenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-2-methoxy-6-methylbenzoic acid

There total 6 articles about 4-bromo-2-methoxy-6-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-bromo-2-methoxy-6-methylbenzamide (877149-12-7) → 4-bromo-2-methoxy-6-methyl-benzoic acid (877149-08-1)

Guidance literature:

With nitrosylsulfuric acid; water; In dichloromethane; at 0 ℃; for 2h;

Reference yield: 90.0%

4-bromo-2-methoxy-6-methyl-benzaldehyde (1244949-43-6) → 4-bromo-2-methoxy-6-methyl-benzoic acid (877149-08-1)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 23 ℃; for 0.5h;

Reference yield:

4-bromo-2-methoxy-6-methyl-benzonitrile (877149-05-8) → 4-bromo-2-methoxy-6-methyl-benzoic acid (877149-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -78 - 20 °C

1.2: 0 - 20 °C

2.1: 2-methyl-but-2-ene; water; sodium chlorite; sodium dihydrogenphosphate / tert-butyl alcohol / 0.5 h / 20 °C

2.2: pH 1

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; water; diisobutylaluminium hydride; In tetrahydrofuran; toluene; tert-butyl alcohol;

upstream raw materials:

4-bromo-2-methoxy-6-methylbenzamide

4-bromo-2-methoxy-6-methyl-phenylamine

4-bromo-2-methoxy-6-methyl-benzonitrile

4-bromo-2-methoxy-6-methyl-benzaldehyde

Downstream raw materials:

phenyl 4-(benzyloxy)-2-isopropyl-6-methyl-7-(trifluoromethyl)isoindoline-5-carboxylate

phenyl 4-ethenyl-2-methoxy-6-methylbenzoate

phenyl 4-formyl-2-methoxy-6-methylbenzoate

C₁₆H₁₃BrO₄

Refernces

• 1、 -. "SUBSTITUTED 4-AMINOBENZAMIDES AS KCNQ2/3 MODULATORS". . . Retrieved 2013/11/05.
• 2、 -. "SUBSTITUTED 4-AMINOBENZAMIDES AS KCNQ2/3 MODULATORS". . . Retrieved 2013/11/05.