5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine

Base Information

Chemical Name:5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine
CAS No.:1617498-95-9
Molecular Formula:C₂₁H₂₅FN₆O
Molecular Weight:396.468
Hs Code.:

Synonyms:5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine

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Chemical Property of 5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine

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Technology Process of 5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine

There total 4 articles about 5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.66%

: 1617499-20-3
(5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone

: 1617498-95-9
5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine

Guidance literature:: (5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone; With boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; for 0.5h;

With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

With methanol; In tetrahydrofuran; at 0 ℃; for 6h; Reflux;

Reference yield:

: 1210838-82-6
5-bromo-3-ethynyl-pyridin-2-ylamine

: 1617498-95-9
5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / water; tert-butyl alcohol / 2 h / 80 °C

1.2: 16 h / 80 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

3.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.5 h / 0 °C

3.2: 18 h / 0 - 20 °C

3.3: 6 h / 0 °C / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; boron trifluoride diethyl etherate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water; tert-butyl alcohol;

Reference yield:

: 120153-08-4
4-(dihydroxyboranyl)-2-fluorobenzoic acid

: 1617498-95-9
5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: HATU / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

3.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.5 h / 0 °C

3.2: 18 h / 0 - 20 °C

3.3: 6 h / 0 °C / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trifluoride diethyl etherate; caesium carbonate; HATU; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;