Technology Process of 5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine
There total 4 articles about 5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone;
With
boron trifluoride diethyl etherate;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
With
sodium tetrahydroborate;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 18h;
With
methanol;
In
tetrahydrofuran;
at 0 ℃;
for 6h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium azide / water; tert-butyl alcohol / 2 h / 80 °C
1.2: 16 h / 80 °C
2.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,4-dioxane; water / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation
3.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.5 h / 0 °C
3.2: 18 h / 0 - 20 °C
3.3: 6 h / 0 °C / Reflux
With
tetrakis(triphenylphosphine) palladium(0); sodium azide; boron trifluoride diethyl etherate; caesium carbonate;
In
tetrahydrofuran; 1,4-dioxane; water; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: HATU / N,N-dimethyl-formamide / 18 h / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,4-dioxane; water / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation
3.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.5 h / 0 °C
3.2: 18 h / 0 - 20 °C
3.3: 6 h / 0 °C / Reflux
With
tetrakis(triphenylphosphine) palladium(0); boron trifluoride diethyl etherate; caesium carbonate; HATU;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
