(5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone

Base Information

• Chemical Name: (5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone
• CAS No.: 1617499-20-3
• Molecular Formula: C₂₁H₂₃FN₆O₂
• Molecular Weight: 410.451
• Mol file: 1617499-20-3.mol

Synonyms:(5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone

Chemical Property of (5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone

There total 3 articles about (5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.41%

(3-fluoro-4-(morpholine-4-carbonyl)phenyl)boronic acid (1008119-70-7) + 5-bromo-3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-pyridin-2-ylamine (1617499-16-7) → (5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone (1617499-20-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 110 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

5-bromo-3-ethynyl-pyridin-2-ylamine (1210838-82-6) → (5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone (1617499-20-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium azide / water; tert-butyl alcohol / 2 h / 80 °C

1.2: 16 h / 80 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; caesium carbonate; In 1,4-dioxane; water; tert-butyl alcohol;

Reference yield:

4-(dihydroxyboranyl)-2-fluorobenzoic acid (120153-08-4) → (5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone (1617499-20-3)

Guidance literature:

Multi-step reaction with 2 steps

1: HATU / N,N-dimethyl-formamide / 18 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide;

upstream raw materials:

(3-fluoro-4-(morpholine-4-carbonyl)phenyl)boronic acid

5-bromo-3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-pyridin-2-ylamine

5-bromo-3-ethynyl-pyridin-2-ylamine

4-(dihydroxyboranyl)-2-fluorobenzoic acid

Downstream raw materials:

5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine