tert-Butyl N-[2-(Boc-amino)ethyl]-N-methylcarbamate

Base Information

• Chemical Name: tert-Butyl N-[2-(Boc-amino)ethyl]-N-methylcarbamate
• CAS No.: 105983-83-3
• Molecular Formula: C13H26N2O4
• Molecular Weight: 274.36
• Mol file: 105983-83-3.mol

Synonyms:N,Nμ-Di-Boc-N-methylethylenediamine;N-Boc-2-(Boc-methylamino)ethylamine;tert-Butyl N-[2-(Boc-amino)ethyl]-N-methylcarbamate;N-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]ethyl]-N-methylcarbamic acid 1,1-dimethylethyl ester

Chemical Property of tert-Butyl N-[2-(Boc-amino)ethyl]-N-methylcarbamate

Chemical Property:

• Melting Point: 114-119℃
• PSA: 71.36000
• LogP: 2.58240

Purity/Quality:

99% ^*data from raw suppliers

N,N′-Di-Boc-N-methylethylenediamine 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl N-[2-(Boc-amino)ethyl]-N-methylcarbamate

There total 2 articles about tert-Butyl N-[2-(Boc-amino)ethyl]-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C + palladium on carbon (Pd + [2-(benzyloxycarbonyl-methyl-amino)-ethyl]-dicarbamic acid tert-butyl ester (1276121-44-8) → tert-butyl 2-tert-butyloxycarbonylaminoethyl(methyl)carbamate (105983-83-3)

Guidance literature:

In methanol; ethyl acetate;

Reference yield:

→ tert-butyl 2-tert-butyloxycarbonylaminoethyl(methyl)carbamate (105983-83-3)

Guidance literature:

Reference yield: 80.0%

tert-butyl 2-tert-butyloxycarbonylaminoethyl(methyl)carbamate (105983-83-3) + meta-bromobenzyl bromide (823-78-9) → tert-butyl (2-((3-bromobenzyl)(tert-butoxycarbonyl)amino)-ethyl)(methyl)-carbamate (875339-45-0)

Guidance literature:

tert-butyl 2-tert-butyloxycarbonylaminoethyl(methyl)carbamate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

meta-bromobenzyl bromide; In tetrahydrofuran; for 3h; Heating / reflux;

upstream raw materials:

[2-(benzyloxycarbonyl-methyl-amino)-ethyl]-dicarbamic acid tert-butyl ester

Downstream raw materials:

tert-butyl (2-((3-bromobenzyl)(tert-butoxycarbonyl)amino)-ethyl)(methyl)-carbamate

Refernces

• 1、 -. "COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PRODRUGS OF ACTIVE AGENTS AND INHIBITORS THEREOF". . . Retrieved 2011/11/06.