QUINAZOLINE, 6-BROMO-4-CHLORO-2-(METHYLTHIO)-

Base Information

• Chemical Name: QUINAZOLINE, 6-BROMO-4-CHLORO-2-(METHYLTHIO)-
• CAS No.: 1003043-76-2
• Molecular Formula: C₉H₆BrClN₂S
• Molecular Weight: 289.583
• Hs Code.: 2933990090
• Mol file: 1003043-76-2.mol

Synonyms:QUINAZOLINE, 6-BROMO-4-CHLORO-2-(METHYLTHIO)-;6-broMo-4-chloro-2-(Methylthio)quinazoline;6-bromo-4-chloro-2-(methylsulfanyl)quinazoline

Chemical Property of QUINAZOLINE, 6-BROMO-4-CHLORO-2-(METHYLTHIO)-

Chemical Property:

• PSA: 51.08000
• LogP: 3.76760

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-4-chloro-2-methylsulfanylquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of QUINAZOLINE, 6-BROMO-4-CHLORO-2-(METHYLTHIO)-

There total 3 articles about QUINAZOLINE, 6-BROMO-4-CHLORO-2-(METHYLTHIO)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(methylsulfanyl)-6-bromo-quinazolin-4(3H)-one (174313-65-6) → 6-bromo-4-chloro-2-(methylsulfanyl)quinazoline (1003043-76-2)

Guidance literature:

With pyridine; trichlorophosphate; at 110 ℃; for 18h;

DOI:10.1016/j.bmc.2010.11.050

Reference yield:

6-bromo-2-(methylthio)-quinazolin-4-ol (174313-65-6) → 6-bromo-4-chloro-2-(methylsulfanyl)quinazoline (1003043-76-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; for 6h; Heating / reflux;

Reference yield:

6-Methyl-4-oxo-2-thioxo-1,2,3,4-tetrahydrochinazolin (49681-94-9) → 6-bromo-4-chloro-2-(methylsulfanyl)quinazoline (1003043-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium methylate / methanol; N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 22 h / 20 °C

2.1: pyridine; trichlorophosphate / 18 h / 110 °C

With pyridine; sodium methylate; trichlorophosphate; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

6-bromo-2-(methylthio)-quinazolin-4-ol

2-(methylsulfanyl)-6-bromo-quinazolin-4(3H)-one

6-Methyl-4-oxo-2-thioxo-1,2,3,4-tetrahydrochinazolin

Downstream raw materials:

9-bromo-2-phenyl-5-(methylsulfanyl)[1,2,4]triazolo[4,3-c]-quinazolin-3(2H)-one

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