H2N-PEG4-Propyne

Base Information

Chemical Name:H2N-PEG4-Propyne
CAS No.:1013921-36-2
Molecular Formula:C11H21NO4
Molecular Weight:231.292
Hs Code.:
Mol file:1013921-36-2.mol

Synonyms:H2N-PEG4-Propyne;Acetylene-PEG4-amine;Amino-PEG4-alkyne;Triethylene glycol 2-aminoethyl propargyl ether;Propargyl-PEG4-amine

Suppliers and Price of H2N-PEG4-Propyne

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Acetylene-PEG4-amine
50mg
$ 175.00

Sigma-Aldrich
Amino-PEG4-alkyne
25mg
$ 125.00

Sigma-Aldrich
Amino-PEG4-alkyne
10mg
$ 55.60

purepeg
HC≡C-CH2-PEG4-NH2 min.97%
250 mg
$ 130.00

Iris Biotech GmbH
Alkyne-PEG(4)-NH2
1 g
$ 1188.00

Iris Biotech GmbH
Alkyne-PEG(4)-NH2
100 mg
$ 391.50

chempep
H2N-PEG4-Propyne >=95%
500mg
$ 325.00

chempep
H2N-PEG4-Propyne >=95%
1g
$ 503.00

Chem-Impex
Alkyne-PEG4-amine,≥95%(HPLC) ≥95%(HPLC)
1G
$ 914.37

Chem-Impex
Alkyne-PEG4-amine,95%(HPLC) 95%(HPLC)
25MG
$ 100.80

Total 22 raw suppliers

Chemical Property of H2N-PEG4-Propyne

Chemical Property:

Boiling Point:315.9±32.0 °C(Predicted)
PKA:8.74±0.10(Predicted)
PSA：62.94000
Density:1.037±0.06 g/cm3(Predicted)
LogP:0.34500
Storage Temp.:?20°C
Solubility.:Soluble in DMSO, DMF, DCM, THF, or chloroform.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Acetylene-PEG4-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Propargyl-PEG4-amine has a propargyl group and an amine group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls, etc. The propargyl group can form triazole linkage with azide-bearing biomolecules.
Uses 1-Amino-3,6,9,12-tetraoxapentadec-14-yne is used as a acetylene containing reagent with PEG spacer and carboxyl reactivity. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification of carboxylic acid containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Technology Process of H2N-PEG4-Propyne

There total 15 articles about H2N-PEG4-Propyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1192590-91-2
1-azido-3,6,9,12-tetraoxapentadec-14-yne

: 1013921-36-2,956348-61-1
3,6,9,12-tetraoxapentadec-14-yn-1-amine

Guidance literature:: With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1016/j.chembiol.2019.05.010

Reference yield: 99.0%

: 1422540-93-9
C₁₉H₂₃NO₆

: 1013921-36-2,956348-61-1
3,6,9,12-tetraoxapentadec-14-yn-1-amine

Guidance literature:: With hydrazine; In ethanol; at 60 ℃; for 3h;
DOI:10.1039/c2ob26968f

Reference yield: 96.0%

: 1219810-90-8
tert-butyl N-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl]carbamate

: 1013921-36-2,956348-61-1
3,6,9,12-tetraoxapentadec-14-yn-1-amine

Guidance literature:: tert-butyl N-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl]carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With sodium hydroxide; In water; pH=14; Inert atmosphere;
DOI:10.1021/ja203286n