tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate

Base Information

• Chemical Name: tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate
• CAS No.: 1207175-73-2
• Molecular Formula: C10H13BrN2O3
• Molecular Weight: 289.129
• Hs Code.: 2933399090
• Mol file: 1207175-73-2.mol

Synonyms:tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate;2-(Boc-amino)-5-bromo-3-hydroxypyridine

Chemical Property of tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate

Chemical Property:

• Boiling Point: 363.8±42.0 °C(Predicted)
• PKA: 8.02±0.10(Predicted)
• PSA: 74.94000
• Density: 1.552
• LogP: 2.91030
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(5-Bromo-3-hydroxypyridin-2-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate

There total 5 articles about tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-3-hydroxy-5-bromopyridine (39903-01-0) → 5-bromo-3-hydroxy-2-tert-butyloxycarbonylaminopyridine (1207175-73-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 40.9%

6-bromo-3H-oxazolo[4,5-b]pyridin-2-one (21594-52-5) + di-tert-butyl dicarbonate (24424-99-5) → 5-bromo-3-hydroxy-2-tert-butyloxycarbonylaminopyridine (1207175-73-2)

Guidance literature:

With dmap; triethylamine; In ethanol; at 20 ℃; Inert atmosphere;

Reference yield:

2-amino-3-hydroxypyridine (16867-03-1) → 5-bromo-3-hydroxy-2-tert-butyloxycarbonylaminopyridine (1207175-73-2)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 1,2-dichloro-ethane / 3 h / Reflux

2: bromine / N,N-dimethyl-formamide / 2 h / 0 - 30 °C

3: sodium hydroxide; water / 6 h / 100 °C

4: triethylamine / dichloromethane / 12 h / 20 - 30 °C

With pyridine; water; bromine; triethylamine; sodium hydroxide; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2014.01.053

upstream raw materials:

2-amino-3-hydroxypyridine

di-tert-butyl dicarbonate

2-amino-3-hydroxy-5-bromopyridine

2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one

Downstream raw materials:

crizotinib

(+/-)-PF023401066

lorlatinib

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1207175-73-2 tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate

Send

Send

Metric Ton KG G Pound L ML

Send

Send